The evolving complexity of the podocyte cytoskeleton

C Schell, TB Huber - Journal of the American Society of …, 2017 - journals.lww.com
Podocytes exhibit a unique cytoskeletal architecture that is fundamentally linked to their
function in maintaining the kidney filtration barrier. The cytoskeleton regulates podocyte …

Seaweed secondary metabolites in vitro and in vivo anticancer activity

DHA Rocha, AML Seca, DCGA Pinto - Marine drugs, 2018 - mdpi.com
Isolation, finding or discovery of novel anticancer agents is very important for cancer
treatment, and seaweeds are one of the largest producers of chemically active metabolites …

A new eigenvalue problem solver for thermo‐mechanical vibration of Timoshenko nanobeams by an innovative nonlocal finite element method

HM Numanoğlu, H Ersoy, B Akgöz… - … Methods in the Applied …, 2022 - Wiley Online Library
In this study, size‐dependent thermo‐mechanical vibration analysis of nanobeams is
examined. Size‐dependent dynamic equations are obtained by implementing Hamilton's …

Asymmetric molecular architecture of the human γ-tubulin ring complex

M Wieczorek, L Urnavicius, SC Ti, KR Molloy, BT Chait… - Cell, 2020 - cell.com
The γ-tubulin ring complex (γ-TuRC) is an essential regulator of centrosomal and
acentrosomal microtubule formation, yet its structure is not known. Here, we present a cryo …

A choreography of centrosomal mRNAs reveals a conserved localization mechanism involving active polysome transport

A Safieddine, E Coleno, S Salloum, A Imbert… - Nature …, 2021 - nature.com
Local translation allows for a spatial control of gene expression. Here, we use high-
throughput smFISH to screen centrosomal protein-coding genes, and we describe 8 human …

Evaluation of Bacillus subtilis as a probiotic to Indian major carp Labeo rohita (Ham.)

R Kumar, SC Mukherjee, KP Prasad… - Aquaculture …, 2006 - Wiley Online Library
Bacillus subtilis, a Gram‐positive, aerobic, endospore‐forming bacterium, was evaluated for
its probiotic potential in Indian major carp, Labeo rohita. Labeo rohita (15±2 g) were fed a …

Mitotic cells generate protrusive extracellular forces to divide in three-dimensional microenvironments

S Nam, O Chaudhuri - Nature Physics, 2018 - nature.com
During mitosis, or cell division, mammalian cells undergo extensive morphological changes,
including elongation along the mitotic axis, which is perpendicular to the plane that bisects …

Failure of DNA double-strand break repair by tau mediates Alzheimer's disease pathology in vitro

M Asada-Utsugi, K Uemura, T Ayaki… - Communications …, 2022 - nature.com
DNA double-strand break (DSB) is the most severe form of DNA damage and accumulates
with age, in which cytoskeletal proteins are polymerized to repair DSB in dividing cells …

Comprehensive understanding of anchorage-independent survival and its implication in cancer metastasis

Z Deng, H Wang, J Liu, Y Deng, N Zhang - Cell Death & Disease, 2021 - nature.com
Detachment is the initial and critical step for cancer metastasis. Only the cells that survive
from detachment can develop metastases. Following the disruption of cell–extracellular …

Microtubule-targeting drugs: more than antimitotics

R Kaul, AL Risinger, SL Mooberry - Journal of natural products, 2019 - ACS Publications
Nature has yielded numerous compounds that bind to tubulin/microtubules and disrupt
microtubule function. Even with the advent of targeted therapies for cancer, natural products …