Defining optimal brain health in adults: a presidential advisory from the American Heart Association/American Stroke Association

PB Gorelick, KL Furie, C Iadecola, EE Smith, SP Waddy… - Stroke, 2017 - Am Heart Assoc
Cognitive function is an important component of aging and predicts quality of life, functional
independence, and risk of institutionalization. Advances in our understanding of the role of …

Cholesterol: its regulation and role in central nervous system disorders

M Orth, S Bellosta - Cholesterol, 2012 - Wiley Online Library
Cholesterol is a major constituent of the human brain, and the brain is the most cholesterol‐
rich organ. Numerous lipoprotein receptors and apolipoproteins are expressed in the brain …

The Role of Cholesterol in α‐Synuclein and Lewy Body Pathology in GBA1 Parkinson's Disease

P García‐Sanz, J MFG Aerts… - Movement Disorders, 2021 - Wiley Online Library
Parkinson's disease (PD) is a progressive neurodegenerative disease where dopaminergic
neurons in the substantia nigra are lost, resulting in a decrease in striatal dopamine and …

[HTML][HTML] A possible link between food and mood: dietary impact on gut microbiota and behavior in BALB/c mice

BP Jørgensen, JT Hansen, L Krych, C Larsen… - PloS one, 2014 - journals.plos.org
Major depressive disorder is a debilitating disease in the Western World. A western diet high
in saturated fat and refined sugar seems to play an important part in disease development …

Long-term pioglitazone treatment improves learning and attenuates pathological markers in a mouse model of Alzheimer's disease

JL Searcy, JT Phelps, T Pancani… - Journal of …, 2012 - journals.sagepub.com
Thiazolidinediones (TZDs) are agonists at peroxisome proliferator-activated gamma-type
(PPAR-γ) receptors and are used clinically for the treatment of type 2 diabetes where they …

Cardiovascular disease, the nitric oxide pathway and risk of cognitive impairment and dementia

BCM Stephan, SL Harrison, HAD Keage… - Current cardiology …, 2017 - Springer
Abstract Purpose of Review In this review, we summarise the evidence on the association
between cardiovascular disease (CVD) and cognitive impairment and explore the role of the …

Cholesterol modulates open probability and desensitization of NMDA receptors

M Korinek, V Vyklicky, J Borovska… - The Journal of …, 2015 - Wiley Online Library
Key points NMDA receptors (NMDARs) are tetrameric cation channels permeable to
calcium; they mediate excitatory synaptic transmission in the CNS and their excessive …

Effect of selenium-enriched probiotics on laying performance, egg quality, egg selenium content, and egg glutathione peroxidase activity

C Pan, Y Zhao, SF Liao, F Chen, S Qin… - Journal of agricultural …, 2011 - ACS Publications
A 35-day experiment was conducted to evaluate the effect of selenium-enriched probiotics
(SP) on laying performance, egg quality, egg selenium (Se) content, and egg glutathione …

A practical application of generative adversarial networks for RNA-seq analysis to predict the molecular progress of Alzheimer's disease

J Park, H Kim, J Kim, M Cheon - PLoS computational biology, 2020 - journals.plos.org
Next-generation sequencing (NGS) technology has become a powerful tool for dissecting
the molecular and pathological signatures of a variety of human diseases. However, the …

Can cholesterol metabolism modulation affect brain function and behavior?

V Cartocci, M Servadio, V Trezza… - Journal of cellular …, 2017 - Wiley Online Library
Cholesterol is an important component for cell physiology. It regulates the fluidity of cell
membranes and determines the physical and biochemical properties of proteins. In the …