Telomerase as a therapeutic target in glioblastoma

E Aquilanti, L Kageler, PY Wen, M Meyerson - Neuro-oncology, 2021 - academic.oup.com
Glioblastoma is the most common primary malignant brain tumor in adults and it continues to
have a dismal prognosis. The development of targeted therapeutics has been particularly …

[HTML][HTML] Anticancer properties of complexes derived from bidentate ligands

DI Ugwu, J Conradie - Journal of Inorganic Biochemistry, 2023 - Elsevier
Cancer is the abnormal division and multiplication of cells in an organ or tissue. It is the
second leading cause of death globally. There are various types of cancer such as prostate …

[HTML][HTML] Reclassification of glioblastoma multiforme according to the 2021 World Health Organization classification of central nervous system tumors: a single …

GS Stoyanov, E Lyutfi, R Georgieva, R Georgiev… - Cureus, 2022 - ncbi.nlm.nih.gov
Materials and methods A retrospective, non-clinical approach was utilized. Biopsy
specimens of adults diagnosed with GBM, WHO grade 4, NOS in the period February 2018 …

Survival of glioblastoma in relation to tumor location: a statistical tumor atlas of a population-based cohort

EH Fyllingen, LE Bø, I Reinertsen, AS Jakola… - Acta …, 2021 - Springer
Purpose Previous studies on the effect of tumor location on overall survival in glioblastoma
have found conflicting results. Based on statistical maps, we sought to explore the effect of …

Preparation and characterization of size-controlled glioma spheroids using agarose hydrogel microwells

F Mirab, YJ Kang, S Majd - PloS one, 2019 - journals.plos.org
Treatment of glioblastoma, the most common and aggressive type of primary brain tumors, is
a major medical challenge and the development of new alternatives requires simple yet …

PerSurge (NOA-30) phase II trial of perampanel treatment around surgery in patients with progressive glioblastoma

S Heuer, I Burghaus, M Gose, T Kessler, F Sahm… - BMC cancer, 2024 - Springer
Background Glioblastoma is the most frequent and a particularly malignant primary brain
tumor with no efficacy-proven standard therapy for recurrence. It has recently been …

Agent-based computational modeling of glioblastoma predicts that stromal density is central to oncolytic virus efficacy

AL Jenner, M Smalley, D Goldman, WF Goins… - Iscience, 2022 - cell.com
Oncolytic viruses (OVs) are emerging cancer immunotherapy. Despite notable successes in
the treatment of some tumors, OV therapy for central nervous system cancers has failed to …

Growth exponents reflect evolutionary processes and treatment response in brain metastases

B Ocaña-Tienda, J Pérez-Beteta… - npj Systems Biology …, 2023 - nature.com
Tumor growth is the result of the interplay of complex biological processes in huge numbers
of individual cells living in changing environments. Effective simple mathematical laws have …

A framework for standardised tissue sampling and processing during resection of diffuse intracranial glioma: joint recommendations from four RANO groups

P Karschnia, M Smits, G Reifenberger… - The Lancet …, 2023 - thelancet.com
Surgical resection represents the standard of care for people with newly diagnosed diffuse
gliomas, and the neuropathological and molecular profile of the resected tissue guides …

The direction of tumour growth in glioblastoma patients

M Esmaeili, AL Stensjøen, EM Berntsen, O Solheim… - Scientific reports, 2018 - nature.com
Generating MR-derived growth pattern models for glioblastoma multiforme (GBM) has been
an attractive approach in neuro-oncology, suggesting a distinct pattern of lesion spread with …