Crucial as molecular sensors for many vital physiological processes, seven-transmembrane
domain G protein-coupled receptors (GPCRs) comprise the largest family of proteins …

The endocannabinoid system (ECS) acts as a negative feedback mechanism to suppress
synaptic transmission and plays a major role in a diverse range of brain functions including …

Crystallography has advanced our understanding of G protein–coupled receptors, but low
expression levels and instability in solution have limited structural insights to very few …

Apelin receptor (APJR) is a class A peptide (apelin) binding G protein-coupled receptor
(GPCR) that plays a significant role in regulating blood pressure, cardiac output, and …

G protein-coupled receptors (GPCRs) are transmembrane receptors that convert
extracellular stimuli to intracellular signals. The type 1 angiotensin II receptor is a widely …

Several key amino acids within amphipathic helix 8 of the human β 1-adrenergic receptor (β
1-AR) were mutagenized to characterize their role in signaling by G protein-coupled …

Upon activation the human bradykinin B 2 receptor (B 2 R) acts as guanine nucleotide
exchange factor for the G proteins G q/11 and G i. Thereafter, it gets phosphorylated by G …

For most cell culture experiments, it is indispensable that the cells are firmly anchored to
culture plates, withstanding rinsing steps that can create shear forces and tolerating …

Bradykinin-related peptides, universal mediators of inflammation collectively referred to as
the kinins, are often produced in excessive amounts during microbial infections. We have …

In recent years a wide range of studies have shown that G protein-coupled receptors
modulate a variety of cell functions through the formation of dimers. For instance, there is …