Background Colibactin is a genotoxin that induces DNA double-strand breaks that may lead
to carcinogenesis and is produced by Escherichia coli strains harboring the pks island …

The idea that bacterial toxins are not only killers but also execute more sophisticated roles
during bacteria–host interactions by acting as negotiators has been highlighted in the past …

E. coli is one of the most common species of bacteria colonizing humans and animals. The
singularity of E. coli's genus and species underestimates its multifaceted nature, which is …

Colorectal cancer (CRC) is the third most prevalent cause of tumorigenesis and several
pathogenic bacteria have been correlated with aggressive cases of cancer ie, genotoxin …

Neuroblastoma (NB), derived from the neural crest (NC), is the most common pediatric
extracranial solid tumor. Here, we establish a platform that allows the study of human NBs in …

Objective: The incidence of colorectal cancer has increased dramatically in recent years.
One of the most important causes of colorectal cancer is infection with a specific type of …

Inclusion body nephropathy (IBN) and kidney fibrosis in aged immunodeficient mice and, to
lesser extent, in immunocompetent mice have been recently linked to infection of mouse …

Cyclomodulins are virulence factors that modulate cellular differentiation, apoptosis, and
proliferation. These include colibactin (pks), cytotoxic necrotizing factor (cnf), and cytolethal …

Klebsiella pneumoniae (Kp) is a gram-negative opportunistic pathogen that causes severe
pneumonia, pyelonephritis, and sepsis in immunocompromised hosts. During a 4-mo …

Escherichia coli encoding colibactin (clb), cytolethal distending toxin (cdt), and hemolysin-
associated cytotoxic necrotizing factor (cnf) are associated with various intestinal and extra …