Chromone as a privileged scaffold in drug discovery: recent advances: miniperspective

J Reis, A Gaspar, N Milhazes… - Journal of medicinal …, 2017 - ACS Publications
The use of privileged structures in drug discovery has proven to be an effective strategy,
allowing the generation of innovative hits/leads and successful optimization processes …

Chromones: Privileged scaffold in anticancer drug discovery

VM Patil, N Masand, S Verma… - Chemical Biology & …, 2021 - Wiley Online Library
In the design and discovery of anticancer drugs, various natural heterocyclic scaffolds have
attracted considerable interest as privileged structures. For rational drug design, some of the …

A century-old one-pot multicomponent Biginelli reaction products still finds a niche in drug discoveries: Synthesis, mechanistic studies and diverse biological activities …

S Faizan, TF Roohi, RM Raju, Y Sivamani… - Journal of Molecular …, 2023 - Elsevier
One of the largest classes of organic molecules are dihydropyrimidines and its derivatives.
They are widely used in a variety of pharmacological and industrial applications. Their …

Design, synthesis of new 1, 2, 4-triazole/1, 3, 4-thiadiazole with spiroindoline, imidazo [4, 5-b] quinoxaline and thieno [2, 3-d] pyrimidine from isatin derivatives as …

AA Abu-Hashem, SA Al-Hussain - Molecules, 2022 - mdpi.com
The current work aims to design and synthesis a new series of isatin derivatives and greatly
enhances their cytotoxic activity. The derivatives 3-((bromophenyl) imino)-1-(morpholino …

Synthesis and antibacterial evaluation of novel heterocyclic compounds containing a sulfonamido moiety

ME Azab, MM Youssef, EA El-Bordany - Molecules, 2013 - mdpi.com
Aiming for the synthesis of new heterocyclic compounds containing a sulfonamido moiety
suitable for use as antibacterial agents, the precursor ethyl {[4-N-(4, 6-dimethylpyrimidin-2 …

Chromone-Based Cd (II) Fluorescent Coordination Polymer Fabricated to Study Optoelectronic and Explosive Sensing Properties

J Mandal, A Dey, S Sarkar, M Khatun, P Ghorai… - Inorganic …, 2024 - ACS Publications
Here, electrical conductivity and explosive sensing properties of multifunctional chromone-
Cd (II)-based coordination polymers (CPs)(1–4) have been explored. The presence of …

The Synthesis, Antimicrobial Activity, and Molecular Docking of New 1, 2, 4-Triazole, 1, 2, 4-Triazepine, Quinoline, and Pyrimidine Scaffolds Condensed to Naturally …

AA Abu-Hashem, SA Al-Hussain - Pharmaceuticals, 2022 - mdpi.com
This study aims to synthesize a new series of furochromone derivatives, evaluate their
antimicrobial properties, and improve the permeability of potent compounds to inhibit …

Synthesis, reactions and biological activities of furochromones: A review

AA Abu-Hashem, M El-Shazly - European journal of medicinal chemistry, 2015 - Elsevier
Furochromone derivatives are important synthetic targets which showed a myriad of
interesting biological activities. Ammi visnaga (Umbelliferae) is the most famous source of …

Synthesis, design, and antimicrobial activity of pyrido[2,3‐d][1,2,4]triazolo[4,3‐a]pyrimidinones based on quinoline derivatives

AA Abu‐Hashem, MNM Yousif… - Journal of the …, 2023 - Wiley Online Library
Abstract The pyrido [2, 3‐d] pyrimidine moieties are one of the most biologically widespread
heterocyclic compounds as antimicrobial, antioxidant, antitubercular, antiviral and anti …

[HTML][HTML] Exploring natural products-based cancer therapeutics derived from egyptian flora

HR El-Seedi, N Yosri, SAM Khalifa, Z Guo… - Journal of …, 2021 - Elsevier
Abstract Ethnopharmacological Relevance Egyptian plants are a rich source of natural
molecules, representing considerable biodiversity due to climate variations between the …