Filamentous fungi produce a very wide range of complex and often bioactive metabolites,
demonstrating their inherent ability as hosts of complex biosynthetic pathways. Recent …

A protein's sequence determines its conformational energy landscape. This, in turn,
determines the protein's function. Understanding the evolution of new protein functions …

Non-heme iron (FeII), α-ketoglutarate (α-KG)-dependent oxygenases are a family of
enzymes that catalyze an array of transformations that cascade forward after the formation of …

Direct aromatization of cyclohexanones to synthesize substituted phenols represents a
significant challenge in modern synthetic chemistry. Herein, we describe a novel ene …

Flavoenzymes can mediate a large variety of oxidation reactions through the activation of
oxygen. However, the O2 activation chemistry of flavin enzymes is not yet fully exploited …

Selective, one‐step C− H activation of fatty acids from biomass is an attractive concept in
sustainable chemistry. Biocatalysis has shown promise for generating high‐value hydroxy …

The stereoselectivity of enzymes plays a central role in asymmetric biocatalytic reactions, but
there remains a dearth of evolution-driven biochemistry studies investigating the …

Oxygen plays a crucial role in the metabolic processes of non-anaerobic organisms.
However, a detailed understanding of how triplet oxygen participates in the enzymatic …

Biocatalysis can be powerful in organic synthesis but is often limited by enzymes' substrate
scope and selectivity. Developing a biocatalytic step involves identifying an initial enzyme …

Conspectus Active transport is a vital and ubiquitous process in biological phenomena. Ion-
pumping rhodopsins are light-driven active ion transporters that share a heptahelical …