Macrophages are present in all tissues, either as resident cells or monocyte-derived cells
that infiltrate into tissues. The tissue site largely determines the phenotype of tissue-resident …

Here, we define dynamic reciprocity (DR) as an ongoing, bidirectional interaction among
cells and their surrounding microenvironment. In this review, we posit that DR is especially …

Uncontrolled macrophage activation is now considered to be a critical event in the
pathogenesis of chronic inflammatory diseases such as atherosclerosis, multiple sclerosis …

The liver has a remarkable capacity to regenerate after injury; yet, the role of macrophages
(MF) in this process remains controversial mainly due to difficulties in distinguishing …

Phagocytosis serves as one of the key processes involved in development, maintenance of
tissue homeostasis, as well as in eliminating pathogens from an organism. Under normal …

Proper activation of macrophages (Mφ) in the inflammatory phase of acute wound healing is
essential for physiological tissue repair. However, there is a strong indication that robust Mφ …

Significance: Macrophages are invariably present and tightly regulate all phases of adult
wound healing, including inflammation, granulation tissue formation, and matrix deposition …

Wounds notoriously accumulate lactate as a consequence of both anaerobic and aerobic
glycolysis following microcirculation disruption, immune activation, and increased cell …

The skin and its appendages comprise the largest and fastest growing organ in the body. It
performs multiple tasks and maintains homeostatic control, including the regulation of body …

Renal fibrosis is a key determinant of the progression of renal disease irrespective of the
original cause and thus can be regarded as a final common pathway that dictates eventual …