Primary aldosteronism is the most common and curable form of secondary arterial
hypertension. We performed whole-exome sequencing in patients with early-onset primary …

ClC-2 transports chloride ions across plasma membranes and plays critical roles in cellular
homeostasis. Its dysfunction is involved in diseases including leukodystrophy and primary …

Background Sudden cardiac arrest is the leading mode of death in the United States.
Epilepsy affects 1% of Americans; yet epidemiological data show a prevalence of 4% in …

Heterozygous mutations in the CLCN2 gene encoding the voltage‐gated chloride channel
CLC2 have been identified in patients with idiopathic generalized epilepsy (IGE). Yet the …

CLC-2 is a voltage-gated chloride channel that contributes to electrical excitability and ion
homeostasis in many different tissues. Among the nine mammalian CLC homologs, CLC-2 …

The widely expressed chloride channel ClC-2 is stimulated by the serum and glucocorticoid
inducible kinase SGK1. The SGK1-dependent regulation of several carriers involves the …

The Na+, glutamate cotransporter EAAT3 is expressed in a wide variety of tissues. It
accomplishes transepithelial transport and the cellular uptake of acidic amino acids …

ClC-2 is a ubiquitously expressed plasma membrane Cl-channel that reportedly controls the
ionic environment in mouse retina and testis. Beyond that, ClC-2 might sense cellular …

The intestinal mucosal barrier is critical to prevent the invasion of the host by pathogens and
toxic products that are present in the intestinal lumen. We studied the role of membrane ion …

The gastric barrier is composed of a single layer of columnar epithelium, mucus and
bicarbonate layer, and the intraepithelial tight junctions residing at the apical-most region of …