Patients undergoing radiation therapy for the head and neck are susceptible to a significant
and often abrupt deterioration in their oral health. The oral morbidities of radiation therapy …

Phosphorus-containing drugs belong to an important class of therapeutic agents and are
widely applied in daily clinical practices. Structurally, the phosphorus-containing drugs can …

Oral and gastrointestinal mucositis caused by high-dose chemotherapy and/or radiation
continues to be an important clinical problem. Fortunately, there have been strategic …

Oral mucositis induced by conventional cytotoxic cancer therapies is a common and
significant clinical problem in oncology. Mucositis symptoms, which include severe pain …

Age is the single greatest risk factor for most causes of morbidity and mortality in humans
and their companion animals. As opposed to other model organisms used to study aging …

Mucositis is one of the most common debilitating side effects related to chemotherapy (CT),
radiation therapy (RT), targeted agents and immunotherapy. It is a complex process …

Biologic drugs have transformed the standard of care for many diseases. However, many
biologics induce the formation of anti-drug antibodies (ADAs), which can compromise their …

Even in healthy aging, cardiac morbidity and mortality increase with age in both mice and
humans. These effects include a decline in diastolic function, left ventricular hypertrophy …

Introduction: Mammalian target of rapamycin (mTOR) inhibitors (sirolimus and everolimus)
are a class of immunosuppressive drugs approved for solid organ transplantation (SOT). By …

Background Oral mucositis is a side effect of chemotherapy, head and neck radiotherapy,
and targeted therapy, affecting over 75% of high risk patients. Ulceration can lead to severe …