Since the discovery of the mechanosensitive Piezo1 channel in 2010, there has been a
significant amount of research conducted to explore its regulatory role in the physiology and …

The malignancy of glioblastoma (GBM), the most aggressive type of human brain tumor,
strongly correlates with the presence of hypoxic areas within the tumor mass. Oxygen levels …

Extracellular biophysical cues such as matrix stiffness are key stimuli tuning cell fate and
affecting tumor progression in vivo. However, it remains unclear how cancer spheroids in a …

Studying cellular mechanoresponses during cancer metastasis is limited by sample
variation or complex protocols that current techniques require. Metastasis is governed by …

The cation channel Piezo1, a crucial mechanotransducer found in various organs and
tissues, has gained considerable attention as a therapeutic target in recent years. Following …

Mechanosensitive ion channel protein 1 (Piezo1) is a large homotrimeric membrane protein.
Piezo1 has various effects and plays an important and irreplaceable role in the maintenance …

Immunomechanobiology, the study of how physical forces influence the behavior and
function of immune cells, is a rapidly growing area of research. It is becoming increasingly …

Purpose Noninvasive cell-type-specific manipulation of neural signaling is critical in basic
neuroscience research and in developing therapies for neurological disorders. Magnetic …

Background Non–small cell lung cancer (NSCLC) is a common malignant tumor with an
increasing incidence. PIEZO-type mechanosensitive ion channel component 1 (PIEZO1) is a …