Background Developmental programming of the embryo is controlled by genetic information
but also dictated by epigenetic information contained in spermatozoa. Lifestyle and …

Mass spectrometry has been widely utilised in the study of nucleobases, nucleosides and
nucleotides as components of nucleic acids and as bioactive metabolites in their own right …

Background DNA methylation plays an essential role in regulating gene expression under a
variety of conditions and it has therefore been hypothesized to underlie the transitions …

In eukaryotes, actual DNA methylation patterns provide biologically important information,
for which both, genome-wide and locus-specific methylation at cytosine residues have been …

Abstract DNA methylation (5-methylcytosine, 5-mC) is an important epigenetic mark that has
regulatory roles in a broad range of biological processes and diseases. Aberrant DNA …

Male infertility might be clearly associated with aberrant DNA methylation patterns in human
spermatozoa. An association between oxidative stress and the global methylation status of …

Structure-based DNA modification analysis provides accurate and important information on
genomic DNA changes from epigenetic modifications to various DNA lesions. However …

Short-term storage of sperm is a useful tool to synchronize the availability of male and
female gametes for fertilization in a hatchery. Induced aging by short-term storage has been …

Identification and quantification of chemical DNA modifications provide essential information
on genomic DNA changes, for example, epigenetic modifications and abnormal DNA …

DNA methylation plays an important role in the regulation of gene expression. In normal
cells, transposable elements that constitute approximately 45% of the human genome are …