C. elegans occurs in two natural sexes, the XX hermaphrodite and the XO male, which differ
extensively in anatomy, physiology, and behavior. All somatic differences between the sexes …

The studies of cell fate and lineage specification are fundamental to our understanding of
the development of multicellular organisms. Caenorhabditis elegans has been one of the …

Summary In Caenorhabditis elegans, the Gli-family transcription factor TRA-1 is the terminal
effector of the sex-determination pathway. TRA-1 activity inhibits male development and …

In Caenorhabditis elegans, vulval cell-fate specification involves the activities of multiple
signal transduction and regulatory pathways that include a receptor tyrosine …

The Hedgehog (Hh) signaling pathway promotes pattern formation and cell proliferation in
Drosophila and vertebrates. Hh is a ligand that binds and represses the Patched (Ptc) …

Hedgehog signaling plays pivotal roles in the development and homeostasis of epithelial
barrier tissues. However, whether and how Hedgehog signaling directly regulates innate …

Sexual differentiation is controlled by diverse master regulatory factors across the animal
kingdom. The transcription factor TRA-1 is the master regulator of somatic sexual …

The hermaphrodite Caenorhabditis elegans germline has become a classic model for stem
cell regulation, but the male C. elegans germline has been largely neglected. This work …

Nervous systems display intriguing patterns of sexual dimorphisms across the animal
kingdom, but the mechanisms that generate such dimorphisms remain poorly characterized …

In Drosophila and vertebrates, Hedgehog (Hh) signalling is mediated by a cascade of
genes, which play essential roles in cell proliferation and survival, and in patterning of the …