Apoptotic cell death in pancreatic β-cells is involved in the pathogenesis of diabetes. Signals
from death receptors and DNA damage have been widely accepted as being triggers of …

Maturity-onset diabetes of the young (MODY) is a monogenic disorder that results in a
familial, young-onset non-insulin dependent form of diabetes, typically presenting in lean …

Background Type 2 diabetes shows evidence of underlying heterogeneity. No studies have
assessed whether different causes for diabetes change the response to oral hypoglycaemic …

Endoplasmic reticulum (ER) stress has been implicated in the pathogenesis of ischemic and
neurodegenerative disorders. Treatment of human SH-SY5Y neuroblastoma cells with …

Mice with 50% Pdx1, a homeobox gene critical for pancreatic development, had worsening
glucose tolerance with age and reduced insulin release in response to glucose, KCl, and …

Of all of the epithelial ovarian cancers, clear cell carcinoma (CCC) of the ovary has the worst
prognosis. We applied the oligonucleotide array technique to identify genes generally …

Understanding the genetic factors of diabetes is essential for addressing the global increase
in type 2 diabetes. HNF1A mutations cause a monogenic form of diabetes called maturity …

Both stimulatory and detrimental effects of NEFAs (non-esterified fatty acids) on pancreatic β-
cells have been recognized. Acute exposure of the pancreatic β-cell to high glucose …

Human monogenic diabetes, caused by mutations in genes involved in beta cell
development and function, has been a challenge to study because multiple mouse models …

The signals and molecular mechanisms that regulate the replication of terminally
differentiated β cells are unknown. Here, we report the identification and characterization of …