Herpetic infections have plagued humanity for thousands of years, but only recently have
advances in antiviral medications and supportive treatments equipped physicians to combat …

Herpes simplex virus type 1 (HSV-1) is highly prevalent in humans and can reach the brain
without evident clinical symptoms. Once in the central nervous system (CNS), the virus can …

Neurotropic herpesviruses can establish lifelong infection in humans and contribute to
severe diseases including encephalitis and neurodegeneration. However, the mechanisms …

The importance of the gut microbiome in central nervous system (CNS) diseases has long
been recognized; however, research into this connection is limited, in part, owing to a lack of …

T cells within the central nervous system (CNS) have been generally considered
pathogenic, especially in the context of neuroinflammatory disease. However, recent …

SUMMARY Herpes simplex virus 1 (HSV-1) can be responsible for life-threatening HSV
encephalitis (HSE). The mortality rate of patients with HSE who do not receive antiviral …

The role of the immune response to oncolytic Herpes simplex viral (oHSV) therapy for
glioblastoma is controversial because it might enhance or inhibit efficacy. We found that …

The production of inflammatory proteins by the innate immune system is a tightly
orchestrated procedure that allows the body to efficiently respond to exogenous and …

Herpes labialis remains exceedingly prevalent and is one of the most common human viral
infections throughout the world. Recurrent herpes labialis evolves from the initial viral …

We reported that the ethanol-induced innate immune response by activating TLR4 signaling
triggers gliosis and neuroinflammation. Ethanol also activates other immune receptors, such …