Regulation of MHC class II gene expression by the class II transactivator
W Reith, S LeibundGut-Landmann… - Nature Reviews …, 2005 - nature.com
MHC class II molecules are pivotal for the adaptive immune system, because they guide the
development and activation of CD4+ T helper cells. Fulfilling these functions requires that …
development and activation of CD4+ T helper cells. Fulfilling these functions requires that …
The bare lymphocyte syndrome and the regulation of MHC expression
W Reith, B Mach - Annual review of immunology, 2001 - annualreviews.org
The bare lymphocyte syndrome (BLS) is a hereditary immunodeficiency resulting from the
absence of major istocompatibility complex class II (MHCII) expression. Considering the …
absence of major istocompatibility complex class II (MHCII) expression. Considering the …
CIITA-induced MHC class II expression in mammary adenocarcinoma leads to a Th1 polarization of the tumor microenvironment, tumor rejection, and specific …
L Mortara, P Castellani, R Meazza, G Tosi… - Clinical cancer …, 2006 - AACR
Purpose: We have shown previously that the MHC class II–negative murine TS/A
adenocarcinoma is rejected in vivo if induced to express MHC class II molecules by …
adenocarcinoma is rejected in vivo if induced to express MHC class II molecules by …
MHC class II transactivator CIITA induces cell resistance to Ebola virus and SARS-like coronaviruses
Recent outbreaks of Ebola virus (EBOV) and severe acute respiratory syndrome coronavirus
2 (SARS-CoV-2) have exposed our limited therapeutic options for such diseases and our …
2 (SARS-CoV-2) have exposed our limited therapeutic options for such diseases and our …
Complementation cloning of an MHC class II transactivator mutated in hereditary MHC class II deficiency (or bare lymphocyte syndrome)
V Steimle, LA Otten, M Zufferey, B Mach - Cell, 1993 - cell.com
Hereditary major histocompatibility complex (MHC) class II deficiency (or bare lymphocyte
syndrome) is a form of severe primary immunodeficiency with a total lack of MHC class II …
syndrome) is a form of severe primary immunodeficiency with a total lack of MHC class II …
Phase I/II multicenter trial of a novel therapeutic cancer vaccine, HepaVac-101, for hepatocellular carcinoma
MW Löffler, S Gori, F Izzo, A Mayer-Mokler… - Clinical Cancer …, 2022 - AACR
Purpose: Immunotherapy for hepatocellular carcinoma (HCC) shows considerable promise
in improving clinical outcomes. HepaVac-101 represents a single-arm, first-in-human phase …
in improving clinical outcomes. HepaVac-101 represents a single-arm, first-in-human phase …
CATERPILLER: a novel gene family important in immunity, cell death, and diseases
JPY Ting, BK Davis - Annu. Rev. Immunol., 2005 - annualreviews.org
▪ Abstract The newly discovered CATERPILLER (CLR) gene family encodes proteins with a
variable but limited number of N-terminal domains, followed by a nucleotide-binding domain …
variable but limited number of N-terminal domains, followed by a nucleotide-binding domain …
CIITA-driven MHC class II expressing tumor cells as antigen presenting cell performers: toward the construction of an optimal anti-tumor vaccine
RS Accolla, E Ramia, A Tedeschi, G Forlani - Frontiers in immunology, 2019 - frontiersin.org
Construction of an optimal vaccine against tumors relies on the availability of appropriate
tumor-specific antigens capable to stimulate CD4+ T helper cells (TH) and CD8+ cytolytic T …
tumor-specific antigens capable to stimulate CD4+ T helper cells (TH) and CD8+ cytolytic T …
Class II transactivator: mastering the art of major histocompatibility complex expression
JA Harton, JPY Ting - Molecular and cellular biology, 2000 - Taylor & Francis
Major histocompatibility complex (MHC) class II molecules are the predominant presenters
of exogenous antigens to T helper cells (reviewed in references 21, 77, and 99). These key …
of exogenous antigens to T helper cells (reviewed in references 21, 77, and 99). These key …
Regulation of major histocompatibility complex class II gene expression, genetic variation and disease
Major histocompatibility complex (MHC) class II molecules are central to adaptive immune
responses and maintenance of self-tolerance. Since the early 1970s, the MHC class II …
responses and maintenance of self-tolerance. Since the early 1970s, the MHC class II …