DNA damage and repair in age-related inflammation
Genomic instability is an important driver of ageing. The accumulation of DNA damage is
believed to contribute to ageing by inducing cell death, senescence and tissue dysfunction …
believed to contribute to ageing by inducing cell death, senescence and tissue dysfunction …
SIRT7: the seventh key to unlocking the mystery of aging
Aging is a chronic yet natural physiological decline of the body. Throughout life, humans are
continuously exposed to a variety of exogenous and endogenous stresses, which engender …
continuously exposed to a variety of exogenous and endogenous stresses, which engender …
Sirt6 attenuates chondrocyte senescence and osteoarthritis progression
M Ji, H Jiang, Z Li, R Geng, JZ Hu, YC Lin… - Nature communications, 2022 - nature.com
Sirt6 has been implicated as a key regulator in aging-related diseases, including
osteoarthritis. However, its functional role and molecular mechanism in chondrocyte …
osteoarthritis. However, its functional role and molecular mechanism in chondrocyte …
Emerging roles of SIRT6 in human diseases and its modulators
The biological functions of sirtuin 6 (SIRT6; eg, deacetylation, defatty‐acylation, and mono‐
ADP‐ribosylation) play a pivotal role in regulating lifespan and several fundamental …
ADP‐ribosylation) play a pivotal role in regulating lifespan and several fundamental …
Sirtuin 6: linking longevity with genome and epigenome stability
Sirtuin 6 (SIRT6) has been in the spotlight of aging research because progeroid phenotypes
are associated with SIRT6 deficiency. SIRT6 has multiple molecular functions, including …
are associated with SIRT6 deficiency. SIRT6 has multiple molecular functions, including …
Emerging therapeutic potential of SIRT6 modulators
Sirtuin 6 (SIRT6) is an NAD+-dependent protein deacylase and mono-ADP-
ribosyltransferase of the sirtuin family with a wide substrate specificity. In vitro and in vivo …
ribosyltransferase of the sirtuin family with a wide substrate specificity. In vitro and in vivo …
Novel 1, 4-dihydropyridines as specific binders and activators of SIRT3 impair cell viability and clonogenicity and downregulate hypoxia-induced targets in cancer …
The mitochondrial SIRT3 modulates several biological pathways such as cancer,
metabolism, and hypoxia-related diseases. Recently, we discovered new 1, 4 …
metabolism, and hypoxia-related diseases. Recently, we discovered new 1, 4 …
Molecular mechanisms of astragaloside‑IV in cancer therapy
T Chen, P Yang, Y Jia - International Journal of …, 2021 - spandidos-publications.com
Radix Astragali (RA) is widely used in traditional Chinese medicine (TCM), and
astragaloside IV (AS‑IV) is the most critical component of RA. Previous studies have …
astragaloside IV (AS‑IV) is the most critical component of RA. Previous studies have …
Rational design of allosteric modulators: Challenges and successes
A Chatzigoulas, Z Cournia - Wiley Interdisciplinary Reviews …, 2021 - Wiley Online Library
Recent advances in structural biology and computational techniques have revealed
allosteric mechanisms for an abundance of targets leading to the establishment of rational …
allosteric mechanisms for an abundance of targets leading to the establishment of rational …
The two-faced role of SIRT6 in cancer
Simple Summary Cancer therapy relies on the employment of different strategies aimed at
inducing cancer cell death through different mechanisms, including DNA damage and …
inducing cancer cell death through different mechanisms, including DNA damage and …