Canary in the Coal Mine: How Resistance Surveillance in Commensals Could Help Curb the Spread of AMR in Pathogenic Neisseria

M Goytia, CB Wadsworth - Mbio, 2022 - Am Soc Microbiol
Antimicrobial resistance (AMR) is widespread within Neisseria gonorrhoeae populations.
Recent work has highlighted the importance of commensal Neisseria (cN) as a source of …

On the road to strain-resolved comparative metagenomics

N Segata - MSystems, 2018 - Am Soc Microbiol
Metagenomics has transformed microbiology, but its potential has not been fully expressed
yet. From computational methods for digging deeper into metagenomes to study designs for …

Site Specialization of Human Oral Veillonella Species

JJ Giacomini, J Torres-Morales, FE Dewhirst… - Microbiology …, 2023 - Am Soc Microbiol
Veillonella species are abundant members of the human oral microbiome with multiple
interspecies commensal relationships. Examining the distribution patterns of Veillonella …

Genetic similarity of gonococcal homologs to meningococcal outer membrane proteins of serogroup B vaccine

H Marjuki, N Topaz, SJ Joseph, KM Gernert, EN Kersh… - MBio, 2019 - Am Soc Microbiol
The human pathogens Neisseria gonorrhoeae and Neisseria meningitidis share high
genome identity. Retrospective analysis of surveillance data from New Zealand indicates the …

Type IV pilus retraction is required for Neisseria musculi colonization and persistence in a natural mouse model of infection

KA Rhodes, MA Rendón, MC Ma, A Agellon… - Mbio, 2024 - Am Soc Microbiol
Retraction of the pathogenic Neisseria Type IV pilus (Tfp) requires PilT, the primary
retraction motor, and its paralogs PilU and PilT2. The importance of Tfp retraction for natural …

Unveiling the immune dynamics of Neisseria persistent oral colonization

M Alles, M Gunasena, T Zia, A D'Mello… - Infection and …, 2024 - Am Soc Microbiol
Commensal bacteria are crucial in maintaining host physiological homeostasis, immune
system development, and protection against pathogens. Despite their significance, the …

Peptidoglycan fragment release and NOD activation by commensal Neisseria species from humans and other animals

TN Harris-Jones, JM Chan, KT Hackett… - Infection and …, 2024 - Am Soc Microbiol
Neisseria gonorrhoeae, a human restricted pathogen, releases inflammatory peptidoglycan
(PG) fragments that contribute to the pathophysiology of pelvic inflammatory disease. The …

Rolling the evolutionary dice: Neisseria commensals as proxies for elucidating the underpinnings of antibiotic resistance mechanisms and evolution in human …

KM Frost, SL Charron-Smith, TC Cotsonas… - Microbiology …, 2024 - Am Soc Microbiol
Species within the genus Neisseria are adept at sharing adaptive allelic variation, with
commensal species repeatedly transferring resistance to their pathogenic relative Neisseria …

Genome-Centric Dynamics Shape the Diversity of Oral Bacterial Populations

DR Utter, CM Cavanaugh, GG Borisy - Mbio, 2022 - Am Soc Microbiol
Two major viewpoints have been put forward for how microbial populations change, differing
in whether adaptation is driven principally by gene-centric or genome-centric processes …