The platelet lifeline to cancer: challenges and opportunities
M Haemmerle, RL Stone, DG Menter… - Cancer cell, 2018 - cell.com
Besides their function in limiting blood loss and promoting wound healing, experimental
evidence has highlighted platelets as active players in all steps of tumorigenesis including …
evidence has highlighted platelets as active players in all steps of tumorigenesis including …
[HTML][HTML] Platelet secretion: From haemostasis to wound healing and beyond
EM Golebiewska, AW Poole - Blood reviews, 2015 - Elsevier
Upon activation, platelets secrete more than 300 active substances from their intracellular
granules. Platelet dense granule components, such as ADP and polyphosphates, contribute …
granules. Platelet dense granule components, such as ADP and polyphosphates, contribute …
Platelet-derived HMGB1 is a critical mediator of thrombosis
Thrombosis and inflammation are intricately linked in several major clinical disorders,
including disseminated intravascular coagulation and acute ischemic events. The damage …
including disseminated intravascular coagulation and acute ischemic events. The damage …
Role of platelet mitochondria: life in a nucleus-free zone
Platelets are abundant, small, anucleate circulating cells, serving many emerging
pathophysiological roles beyond hemostasis; including active critical roles in thrombosis …
pathophysiological roles beyond hemostasis; including active critical roles in thrombosis …
Platelets and cancer: a casual or causal relationship: revisited
Human platelets arise as subcellular fragments of megakaryocytes in bone marrow. The
physiologic demand, presence of disease such as cancer, or drug effects can regulate the …
physiologic demand, presence of disease such as cancer, or drug effects can regulate the …
Expanding applications of allogeneic platelets, platelet lysates, and platelet extracellular vesicles in cell therapy, regenerative medicine, and targeted drug delivery
Platelets are small anucleated blood cells primarily known for their vital hemostatic role.
Allogeneic platelet concentrates (PCs) collected from healthy donors are an essential …
Allogeneic platelet concentrates (PCs) collected from healthy donors are an essential …
Platelet in thrombo-inflammation: Unraveling new therapeutic targets
In the broad range of human diseases, thrombo-inflammation appears as a clinical
manifestation. Clinically, it is well characterized in context of superficial thrombophlebitis that …
manifestation. Clinically, it is well characterized in context of superficial thrombophlebitis that …
[HTML][HTML] The dual role of platelet‐innate immune cell interactions in thrombo‐inflammation
Beyond their role in hemostasis and thrombosis, platelets are increasingly recognized as
key regulators of the inflammatory response under sterile and infectious conditions. Both …
key regulators of the inflammatory response under sterile and infectious conditions. Both …
Current concepts and novel targets for antiplatelet therapy
M Gawaz, T Geisler, O Borst - Nature Reviews Cardiology, 2023 - nature.com
Platelets have a crucial role in haemostasis and atherothrombosis. Pharmacological control
of platelet hyper-reactivity has become a cornerstone in the prevention of thrombo …
of platelet hyper-reactivity has become a cornerstone in the prevention of thrombo …
Blood platelets and sepsis pathophysiology: a new therapeutic prospect in critical ill patients?
A Dewitte, S Lepreux, J Villeneuve, C Rigothier… - Annals of intensive …, 2017 - Springer
Beyond haemostasis, platelets have emerged as versatile effectors of the immune response.
The contribution of platelets in inflammation, tissue integrity and defence against infections …
The contribution of platelets in inflammation, tissue integrity and defence against infections …