Histone lactylation, an indicator of lactate level and glycolysis, has intrinsic connections with
cell metabolism that represents a novel epigenetic code affecting the fate of cells including …

Lactate has long been considered a cellular waste product. However, we found that as
extracellular lactate accumulates, it also enters the mitochondrial matrix and stimulates …

Autophagy is a dynamic process that maintains the normal homeostasis of cells by digesting
and degrading aging proteins and damaged organelles. The effect of autophagy on neural …

Lactic acid (LA) metabolism in the tumor microenvironment contributes to the establishment
and maintenance of immune tolerance. This pathway is characterized in tumor associated …

Impaired autophagy is a hallmark of diabetes. The current study proposed to investigate if
high intensity interval training (HIIT) induced lactate accumulation could stimulate autophagy …

Age-related macular degeneration is a common cause of blindless among the aged, which
can mainly be attributed to oxidative stress and dysregulated autophagy in retinal pigment …

Abstract l-lactate is a catabolite from the anaerobic metabolism of glucose, which plays a
paramount role as a signaling molecule in various steps of the cell survival. Its activity, as a …

Generally, skeletal muscle adaptations to exercise are perceived through a dichotomous
lens where the metabolic stress imposed by aerobic training leads to increased …

Introduction Nutritional support is potentially considered an essential step to prevent muscle
loss and enhance physical function in older adults. Objectives This study aimed to assess …

Cachexia is a multifactorial syndrome characterized by muscle loss that cannot be reversed
by conventional nutritional support. To uncover the molecular basis underlying the onset of …