Hydrogen isotopes are unique tools for identifying and understanding biological and
chemical processes. Hydrogen isotope labelling allows for the traceless and direct …

Life at the molecular level is a dynamic world, where the key players─ proteins,
oligonucleotides, lipids, and carbohydrates─ are in a perpetual state of structural flux …

The activation and functionalization of C–F bonds for the construction of C–C and C–X
bonds have drawn significant research attention in recent years. However, the chemo-and …

Site‐selective incorporation of deuterium into biologically active compounds is of high
interest in pharmaceutical industry. We present a mild and environmentally benign metal …

Protein therapeutics have emerged as a major class of biopharmaceuticals over the past
several decades, a trend that has motivated the advancement of bioanalytical technologies …

Wasserstoffisotope sind einzigartige Werkzeuge zur Identifizierung und Erforschung
biologischer oder chemischer Vorgänge. Wasserstoffisotopenmarkierungen erlauben den …

Metabolic flux analysis (MFA) is an increasingly important tool to study metabolism
quantitatively. Unlike the concentrations of metabolites, the fluxes, which are the rates at …

The budding deuteriodifluoromethyl group (CF2D) is a potentially significant functional
group in medicinal chemistry. Herein, we investigated t-BuOK-catalyzed H/D exchange …

The recent surge in the applications of deuterated drug candidates has rendered an urgent
need for diverse deuterium labeling techniques. Herein, an efficient Rh-catalyzed …

While selective defunctionalizations are valuable in organic synthesis, hydrodeamination of
primary amines poses challenges. Deuterodeamination, analogous to hydrodeamination …