Sepsis remains a major cause of morbidity and mortality in both low-and high-income
countries. Antibiotic therapy and supportive care have significantly improved survival …

Ferroptosis, a unique modality of cell death with mechanistic and morphological differences
from other cell death modes, plays a pivotal role in regulating tumorigenesis and offers a …

Abstract Purpose The Acute Disease Quality Initiative (ADQI) Workgroup recently released a
consensus definition of sepsis-associated acute kidney injury (SA-AKI), combining Sepsis-3 …

Sepsis is a dysregulated host response to an infection, characterized by organ failure. The
pathophysiology is complex and incompletely understood, but mitochondria appear to play a …

Septic shock can be caused by a variety of mechanisms including direct effects of bacterial
toxins such as endotoxin. Annually, approximately 5–7 million patients worldwide develop …

Sepsis has evolved as an enormous health issue amongst critically ill patients. It is a major
risk factor that results in multiple organ failure and shock. Acute kidney injury (AKI) is one of …

Fluid normally exchanges freely between the plasma and interstitial space and is returned
primarily via the lymphatic system. This balance can be disturbed by diseases and …

Acute kidney injury (AKI) is a prototypical example of a common syndrome in critical illness
defined by consensus. The consensus definition for AKI, traditionally defined using only …

Sepsis is a host's deleterious response to infection, which could lead to life-threatening
organ dysfunction. Sepsis-associated acute kidney injury (SA-AKI) is the most frequent …

Worldwide, sepsis is a well-recognized cause of death. Acute kidney injury (AKI) may be
related to sepsis in up to 70% of AKI cases. Sepsis-associated AKI (SA-AKI) is defined as the …