The generation of new lymphatic vessels through lymphangiogenesis and the remodelling
of existing lymphatics are thought to be important steps in cancer metastasis. The past …

Hyaluronan is an extracellular and cell-surface-associated polysaccharide that is
traditionally regarded as a biological'goo'that participates in lubricating joints or holding …

Solid tumor growth and metastasis require the interaction of tumor cells with the surrounding
tissue, leading to a view of tumors as tissue-level phenomena rather than exclusively cell …

CCR7 is implicated in lymph node metastasis of cancer, but its role is obscure. We report a
mechanism explaining how interstitial flow caused by lymphatic drainage directs tumor cell …

Cancer metastases are commonly found in the lymphatic system. Like tumor blood
angiogenesis, stimulation of tumor lymphangiogenesis may require the interplay of several …

Lymphatic metastasis is the main prognostic factor for survival of patients with breast cancer
and other epithelial malignancies. Mounting clinical and experimental data suggest that …

The formation of distant metastases is the deadliest phase of cancer progression. Although
numerous studies have identified genes and mechanisms that affect metastasis after tumors …

Background & Aims: Small liver nodules∼ 2 cm are difficult to characterize by radiologic or
pathologic examination. Our aim was to identify a molecular signature to diagnose early …

Angiogenesis and lymphangiogenesis are essential for breast cancer progression and are
regulated by vascular endothelial growth factors (VEGF). To determine clinical and …

Purpose: Inflammatory breast cancer is a distinct and aggressive form of locally advanced
breast cancer with unique clinical and pathological features. Recently, histologic evidence of …