Metagenomic next-generation sequencing (mNGS) of cerebrospinal fluid (CSF) is an
agnostic method for broad-based diagnosis of central nervous system (CNS) infections …

Metagenomic next-generation sequencing (mNGS) is a novel tool for identifying microbial
DNA and/or RNA in blood and other clinical specimens. In the face of increasingly complex …

Central nervous system (CNS) infections carry a substantial burden of morbidity and
mortality worldwide, and accurate and timely diagnosis is required to optimize management …

The diagnosis of invasive pulmonary aspergillosis (IPA) diseases in non-neutropenic
patients remains challenging. It is essential to develop optimal non-invasive or minimally …

Background Infantile central nervous system infections (CNSIs) can be life-threatening and
cause severe sequelae. However, the causative microorganism remains unknown in> 40 …

Abstract Background Osteoarticular infections (OAIs) are frequently encountered in children.
Treatment may be guided by isolation of a pathogen; however, operative cultures are often …

Central nervous system (CNS) infections can cause significant morbidity and mortality,
especially in children. Rapid and accurate pathogenic detection in suspected CNS …

Central nervous system infections (CNSIs) are common complications after neurosurgery
with a poor prognosis. The traditional microbiological culture methodology has a low …

Introduction Early and accurate identification of pathogens is essential for improved
outcomes in patients with viral encephalitis (VE) and/or viral meningitis (VM). Methods In our …

Antimicrobial resistance (AMR) is a growing public health threat, estimated to cause over 10
million deaths per year and cost the global economy 100 trillion USD by 2050 under status …