Therapeutic effects of proteoliposomes on X-linked chronic granulomatous disease: proof of concept using macrophages differentiated from patient-specific induced …

J Brault, G Vaganay, A Le Roy… - International journal …, 2017 - Taylor & Francis
Chronic granulomatous disease (CGD) is a rare inherited immunodeficiency due to
dysfunction of the phagocytic nicotinamide adenine dinucleotide phosphate (NADPH) …

[HTML][HTML] Role of l-amino acid oxidase isolated from Calloselasma rhodostoma venom on neutrophil NADPH oxidase complex activation

MV Paloschi, CN Boeno, JA Lopes, AES da Rosa… - Toxicon, 2018 - Elsevier
The action of Cr-LAAO, an l-amino acid oxidase isolated from Calloselasma rhodosthoma
snake venom, on NADPH oxidase activation in isolated human neutrophil function was …

Exploring the arachidonic acid‐induced structural changes in phagocyte NADPH oxidase p47phox and p67phox via thiol accessibility and SRCD spectroscopy

T Bizouarn, G Karimi, R Masoud, H Souabni… - The FEBS …, 2016 - Wiley Online Library
The NADPH oxidase is the sole enzymatic complex that produces, in a controlled way,
superoxide anions. In phagocytes, it is constituted by the assembly of four cytosolic …

Conversion of NOX2 into a constitutive enzyme in vitro and in living cells, after its binding with a chimera of the regulatory subunits

R Masoud, X Serfaty, M Erard, P Machillot… - Free Radical Biology …, 2017 - Elsevier
During the phagocytosis of pathogens by phagocyte cells, the NADPH oxidase complex is
activated to produce superoxide anion, a precursor of microbial oxidants. The activated …

Contribution of lipid environment to NADPH oxidase activity: influence of sterol

H Souabni, P Machillot, L Baciou - Biochimie, 2014 - Elsevier
The NADPH-oxidase complex, which plays beneficial or detrimental role in the inflammatory
and degenerative diseases, is a membrane multi-subunit complex tightly regulated in order …

Functional assembly of soluble and membrane recombinant proteins of mammalian NADPH oxidase complex

H Souabni, A Ezzine, T Bizouarn, L Baciou - Membrane Protein Structure …, 2017 - Springer
Activation of phagocyte cells from an innate immune system is associated with a massive
consumption of molecular oxygen to generate highly reactive oxygen species (ROS) as …

A close-up view of the impact of arachidonic acid on the phagocyte NADPH oxidase

T Bizouarn, H Souabni, X Serfaty, A Bouraoui… - … oxidases: Methods and …, 2019 - Springer
The NADPH oxidase NOX2 complex consists of assembled cytosolic and redox membrane
proteins. In mammalian cells, natural arachidonic acid (cis-AA), released by activated …

Une histoire de couleur ou de lumière, 20 ans de pratique expérimentale.

J Dupuy - 2024 - hal.science
Les neurotoxines produites par Clostridium botulinum (BoNTs) sont parmi les plus mortelles
au monde pour l'homme. D'infimes quantités suffisent à causer de sévères paralysies qui …

Exploration de l'interaction p22phox/p47phox: une clé pour comprendre l'assemblage du complexe NADPH oxydase

S Aimeur - 2023 - hal.science
Le complexe NADPH oxydase phagocytaire (NOX2), occupe une place cruciale dans la
génération d'espèces réactives de l'oxygène, jouant un rôle essentiel dans l'immunité innée …

Etude de l'assemblage et de l'activation de la NADPH oxydase de phagocyte au niveau des membranes cellulaires

D Al Abyad - 2022 - theses.hal.science
Les neutrophiles, cellules phagocytaires, détruisent les pathogènes envahissant le corps
humain grâce à une production massive d'espèces réactives de l'oxygène (ERO ou FRO) …