Metabolic Rewiring in Glioblastoma Cancer: EGFR, IDH and Beyond

A El Khayari, N Bouchmaa, B Taib, Z Wei… - Frontiers in …, 2022 - frontiersin.org
Glioblastoma multiforme (GBM), a highly invasive and incurable tumor, is the humans'
foremost, commonest, and deadliest brain cancer. As in other cancers, distinct combinations …

Brain‐targeting drug delivery systems

P Liu, C Jiang - Wiley Interdisciplinary Reviews: Nanomedicine …, 2022 - Wiley Online Library
Brain diseases, including neurodegenerative diseases, acute ischemic stroke and brain
tumors, have become a major health problem and a huge burden on society with high …

[HTML][HTML] Magnetic resonance spectroscopy for the study of cns malignancies

V Ruiz-Rodado, JR Brender, MK Cherukuri… - Progress in nuclear …, 2021 - Elsevier
Despite intensive research, brain tumors are amongst the malignancies with the worst
prognosis; therefore, a prompt diagnosis and thoughtful assessment of the disease is …

Deuterium magnetic resonance spectroscopy enables noninvasive metabolic imaging of tumor burden and response to therapy in low-grade gliomas

C Taglang, G Batsios, J Mukherjee, M Tran… - Neuro …, 2022 - academic.oup.com
Background The alternative lengthening of telomeres (ALT) pathway is essential for tumor
proliferation in astrocytomas. The goal of this study was to identify metabolic alterations …

Metabolic plasticity of IDH1-mutant glioma cell lines is responsible for low sensitivity to glutaminase inhibition

V Ruiz-Rodado, A Lita, T Dowdy, O Celiku… - Cancer & …, 2020 - Springer
Background Targeting glutamine metabolism in cancer has become an increasingly vibrant
area of research. Mutant IDH1 (IDH1 mut) gliomas are considered good candidates for …

Cysteine is a limiting factor for glioma proliferation and survival

V Ruiz‐Rodado, T Dowdy, A Lita, T Kramp… - Molecular …, 2022 - Wiley Online Library
Nutritional intervention is becoming more prevalent as adjuvant therapy for many cancers in
view of the tumor dependence on external sources for some nutrients. However, little is …

[HTML][HTML] Cell-Based Glioma Models for Anticancer Drug Screening: From Conventional Adherent Cell Cultures to Tumor-Specific Three-Dimensional Constructs

D Lanskikh, O Kuziakova, I Baklanov, A Penkova… - Cells, 2024 - mdpi.com
Gliomas are a group of primary brain tumors characterized by their aggressive nature and
resistance to treatment. Infiltration of surrounding normal tissues limits surgical approaches …

Transforming Growth Factor Beta 2 (TGFB2) mRNA Levels, in Conjunction with Interferon-Gamma Receptor Activation of Interferon Regulatory Factor 5 (IRF5) and …

V Trieu, AE Maida, S Qazi - Cancers, 2024 - mdpi.com
Simple Summary Gliomas develop in the central nervous system from the glial cells that
support it. Low-grade gliomas (LGGs) are characterized by a reduced number of immune …

[PDF][PDF] Glioblastoma Multiforme: Molecular Biology and Updated Systematic Review on Natural Extract and Phytochemical Efficacy In-vitro

A Cuschieri, B Baron - JOCAMR, 2023 - researchgate.net
Glioblastoma multiforme (GBM) is the most prevalent primary malignant central nervous
system tumours (CNST). Current treatment consists of surgical resection and adjuvant …

Metabolic biomarkers of radiotherapy response in plasma and tissue of an IDH1 mutant astrocytoma mouse model

V Ruiz-Rodado, T Dowdy, A Lita, T Kramp… - Frontiers in …, 2022 - frontiersin.org
Astrocytomas are the most common subtype of brain tumors and no curative treatment exist.
Longitudinal assessment of patients, usually via Magnetic Resonance Imaging (MRI), is …