Abstract Knowledge of the molecular mechanisms on malignant tumors is very critical for the
development of new treatment strategies like molecularly targeted therapies. In last 5 years …

In mammalian cells, microtubules are present both in interphase and dividing cells. In the
latter, microtubules forming the mitotic spindle are highly dynamic and exquisitely sensitive …

Fork-head box protein M1 (FoxM1) is a transcriptional factor which plays critical roles in
cancer development and progression. However, the general regulatory mechanism of …

Background: Our previous findings showed that miR-33 expressed abnormally in clinical
specimens of melanoma, but the exact molecular mechanism has not been elucidated …

Fetal trophoblasts invade endometrium and establish a complex interaction with the
maternal microenvironment during early pregnancy. However, the molecular mechanisms …

Purpose: Approximately 40% of patients with metastatic melanoma develop brain
metastases. Our purpose was to identify genes aberrantly expressed in melanoma that …

Merkel cell carcinoma (MCC) is an aggressive skin cancer of neuroendocrine origin with a
high propensity for recurrence and metastasis. Merkel cell polyomavirus (MCPyV) causes …

Incidence of cutaneous squamous cell carcinomas (cSCCs) constantly increases in the
Caucasian population. Developing preferentially on precancerous lesions such as actinic …

Protein phosphorylation is an essential post-translational modification (PTM) regulating
many biological processes at the cellular and multicellular level. Continuous improvements …

Background Successful treatment of oesophageal cancer is hampered by recurrent drug
resistant disease. We have previously demonstrated the importance of apoptosis and …