Engineered enzymes for the synthesis of pharmaceuticals and other high-value products
MT Reetz, G Qu, Z Sun - Nature Synthesis, 2024 - nature.com
Catalysis has a central role in organic synthetic methodology, especially in stereoselective
reactions. In many reactions, enantioselectivity is made possible through the use of chiral …
reactions. In many reactions, enantioselectivity is made possible through the use of chiral …
Chemoenzymatic Synthesis of Fluorinated L-α-Amino Acids
X Jin, C Huang, C Cui, H Liu, Z Liu… - ACS Sustainable …, 2024 - ACS Publications
Fluorinated amino acids play a crucial role as fundamental components in drug synthesis
owing to their favorable attributes that enhance the pharmacokinetic properties of drugs …
owing to their favorable attributes that enhance the pharmacokinetic properties of drugs …
Engineered Zea mays phenylalanine ammonia-lyase for improve the catalytic efficiency of biosynthesis trans-cinnamic acid and p-coumaric acid
J Zheng, R Sun, D Wu, P Chen, P Zheng - Enzyme and Microbial …, 2024 - Elsevier
Phenylalanine ammonia-lyase (PAL) plays a pivotal role in the biosynthesis of
phenylalanine. PAL from Zea mays (ZmPAL2) exhibits a bi-function of direct deamination of …
phenylalanine. PAL from Zea mays (ZmPAL2) exhibits a bi-function of direct deamination of …
The Biocatalytic Potential of Aromatic Ammonia–Lyase from Loktanella atrilutea
Abstract Characterization of the aromatic ammonia–lyase from Loktanella atrilutea (LaAAL)
revealed reduced activity towards canonical AAL substrates: l‐Phe, l‐Tyr, and l‐His …
revealed reduced activity towards canonical AAL substrates: l‐Phe, l‐Tyr, and l‐His …
Bioconversion of L-Tyrosine into p-Coumaric Acid by Tyrosine Ammonia-Lyase Heterologue of Rhodobacter sphaeroides Produced in Pseudomonas putida KT2440
CG Calderón, JC Gentina, O Evrard… - Current Issues in …, 2024 - pmc.ncbi.nlm.nih.gov
p-Coumaric acid (p-CA) is a valuable compound with applications in food additives,
cosmetics, and pharmaceuticals. However, traditional production methods are often …
cosmetics, and pharmaceuticals. However, traditional production methods are often …