Endocytosis is a complex process whereby cell surface proteins, lipids and fluid from the
extracellular environment are packaged, sorted and internalized into cells. Endocytosis is …

The physiological function of the epidermal growth factor receptor (EGFR) is to regulate
epithelial tissue development and homeostasis. In pathological settings, mostly in lung and …

Clathrin-mediated endocytosis (CME) is the major endocytic pathway in mammalian cells. It
is responsible for the uptake of transmembrane receptors and transporters, for remodeling …

A potentially important aspect in the regulation of tumour metastasis is endocytosis. This
process consists of internalisation of cell-surface receptors via pinocytosis, phagocytosis or …

Intricate relationships between endocytosis and cellular signaling, first recognized nearly 40
years ago through the study of tyrosine kinase growth factor receptors, are now known to …

Cell surface receptor uptake via clathrin-mediated endocytosis (CME) and subsequent
intracellular sorting for degradation or recycling regulates the strength and specificity of …

Aberrant overexpression or activation of EGFR drives the development of non-small cell
lung cancer (NSCLC) and acquired resistance to EGFR tyrosine kinase inhibitors (TKIs) by …

Alzheimer's disease (AD) and Parkinson's disease (PD) are age-associated
neurodegenerative disorders characterized by the misfolding and aggregation of alpha …

Epithelial-to-mesenchymal transition (EMT) is a transcriptionally governed process by which
cancer cells establish a front-rear polarity axis that facilitates motility and invasion. Dynamic …

Clathrin-mediated endocytosis (CME) begins with the nucleation of clathrin assembly on the
plasma membrane, followed by stabilization and growth/maturation of clathrin-coated pits …