Obesity is a major public health concern. This condition results from a constant and complex
interplay between predisposing genes and environmental stimuli. Current attempts to …

We have identified desmoglein-2 (DSG-2) as the primary high-affinity receptor used by
adenoviruses Ad3, Ad7, Ad11 and Ad14. These serotypes represent key human pathogens …

It is feared that the use of gene transfer technology to enhance athletic performance, the
practice that has received the term 'gene doping', may soon become a real threat to the …

Objective: The paper addresses the degree to which the attainment of the status as an elite
athlete in different sports ameliorates the known age-related losses in skeletal muscle …

Gene therapy for Duchenne muscular dystrophy (DMD) will require sustained expression of
therapeutic dystrophins in striated muscles. Lentiviral vectors have a relatively large …

After only a short history of three decades from concept to practice, gene therapy has
recently been shown to have potential to treat serious human diseases. Despite this …

To explore whether stable transduction of myogenic stem cells using lentiviral vectors could
be of benefit for treating dystrophic muscles, we generated vectors expressing a functional …

Anemia is a common clinical problem, and there is much interest in its role in promoting left
ventricular hypertrophy through increasing cardiac workload. Normally, red blood cell …

Bilirubin is glucuronidated by bilirubin UDP-glucuronyltransferase (UGT1A1) before biliary
excretion. Because bilirubin is toxic, patients with Crigler–Najjar type I (CN), who have no …

Lentiviruses are a subfamily of retroviruses infecting primate and non‐primate hosts. They
have multiple spliced RNA species and several small regulatory proteins that allow …