Purpose: To review the data concerning the role of endogenously generated reactive
oxygen species (ROS) in the non-targeted ionizing radiation (IR) effects and in …

Chronic inflammation has emerged as one of the hallmarks of cancer. Inflammation also
plays a pivotal role in modulating radiation responsiveness of tumors. As discussed in this …

Although radiation therapy (RT) is an integral component of treatment of patients with many
types of cancer, inherent and/or acquired resistance to the cytotoxic effects of RT is …

Double-strand breaks (DSBs), continuously introduced into DNA by cell metabolism,
ionizing radiation and some chemicals, are the biologically most deleterious type of genome …

Radiotherapy is the most significant non-surgical cure for the elimination of tumor, however it
is restricted by two major problems: radioresistance and normal tissue damage. Efficiency …

Purpose: To assess the use of phosphorylated histone H2AX protein (γ-H2AX) in human
blood leukocytes as a rapid screening tool for radiation biodosimetry using a method that …

There is a concern over the potential use of radioactive isotopes as a weapon of terror. The
detonation of a radiation dispersal device, the so-called “dirty bomb” can lead to public …

Cancer treatment is gradually entering an era of precision, with multitude studies in gene
testing and immunotherapy. Tumor cells can be recognized and eliminated by the immune …

DNA double strand breaks (DSBs) are a deleterious form of DNA damage. Densely ionising
alpha radiation predominantly induces complex DSBs and sparsely ionising gamma …

Background: Cancer-related fatigue (CRF) is associated with negative health outcomes and
decreased health-related quality of life; however, few longitudinal studies have investigated …