The complement system is increasingly recognized as important in the pathogenesis of
tissue injury in vivo following immune, ischemic, or infectious insults. Within the complement …

The complement system is a component of the innate immune system. Its main function was
initially believed to be limited to the recognition and elimination of pathogens through direct …

Objective To investigate the safety of therapeutic tumor necrosis factor α (TNFα) blockade in
patients with systemic lupus erythematosus (SLE), in whom this proinflammatory cytokine is …

Some patients with severe systemic lupus erythematosus do not respond to conventional
immunosuppression or suffer severe side effects from such treatment. In order to explore the …

The complement system has once again come into prominence in the therapeutic
development arena. The recent approval of an inhibitory monoclonal antibody, eculizumab …

The passive trapping of preformed immune complexes is responsible for some forms of
glomerulonephritis that are associated with mesangial or subendothelial deposits. The …

The complement system is well known for its role in innate immunity and in maintenance of
tissue homeostasis, providing a first line of defence against infection and playing a key role …

Lupus nephritis is a major complication of systemic lupus erythematosus (SLE) and is
associated with a high rate of morbidity and mortality. While many different immunologic and …

The MRL/lpr murine SLE model has widespread complement activation and deposition of
complement fragments in affected tissues. The potent anaphylatoxin C5a has the potential to …

Background Complement C5 mediates pro-inflammatory responses in many immune-
related renal diseases. Given that the C5a level is elevated in diabetes, we investigated …