Malaria is an illness caused by Plasmodium parasites transmitted to humans by infected
mosquitoes. Of the five species that infect humans, P. falciparum exacts the highest toll in …

Malaria has been a major global health problem of humans through history and is a leading
cause of death and disease across many tropical and subtropical countries. Over the last …

Background Malaria control remains a challenge in many parts of the Sahel and sub-Sahel
regions of Africa. Methods We conducted an individually randomized, controlled trial to …

Modern vaccine design has sought a minimalization approach, moving to the isolation of
antigens from pathogens that invoke a strong neutralizing immune response. This approach …

Background The efficacy and safety of the RTS, S/AS01 candidate malaria vaccine during
18 months of follow-up have been published previously. Herein, we report the final results …

To date, vaccination has become one of the most effective strategies to control and reduce
infectious diseases, preventing millions of deaths worldwide. The earliest vaccines were …

For over 100 years, vaccines have been one of the most effective medical interventions for
reducing infectious disease, and are estimated to save millions of lives globally each year …

Fully effective vaccines for complex infections must elicit a diverse repertoire of antibodies
(humoral immunity) and CD8+ T-cell responses (cellular immunity). Here, we present a …

Background The candidate malaria vaccine RTS, S/AS01 reduced episodes of both clinical
and severe malaria in children 5 to 17 months of age by approximately 50% in an ongoing …

RTS, S is an advanced malaria vaccine candidate and confers significant protection against
Plasmodium falciparum infection in humans. Little is known about the molecular …