Both embryonic and adult stem cells are endowed with a superior capacity to prevent the
accumulation of genetic lesions, repair them, or avoid their propagation to daughter cells …

Aging in mammals is accompanied by a progressive atrophy of tissues and organs, and
stochastic damage accumulation to the macromolecules DNA, RNA, proteins, and lipids …

Abstract CRISPR/Cas9-induced site-specific DNA double-strand breaks (DSBs) can be
repaired by homology-directed repair (HDR) or non-homologous end joining (NHEJ) …

Peribiliary glands (PBG) are a source of stem/progenitor cells organized in a cellular
network encircling large bile ducts. Severe cholangiopathy with loss of luminal biliary …

A now frequently used method to edit mammalian genomes uses the nucleases
CRISPR/Cas9 and CRISPR/Cpf1 or the nickase CRISPR/Cas9n to introduce double-strand …

An important role for the DNA mismatch repair (MMR) pathway in maintaining genomic
stability is embodied in its conservation through evolution and the link between loss of MMR …

Fluorescent proteins have revolutionized biomedical research as they are easy to use for
protein tagging, cope without fixation or permeabilization, and thus, enable live cell imaging …

Background Primary mesenchymal stem cells (MSCs) are fraught with aging-related
shortfalls. Human-induced pluripotent stem cell (iPSC)-derived MSCs (iMSCs) have been …

Safeguarding cell function and identity following a genotoxic stress challenge entails a tight
coordination of DNA damage signaling and repair with chromatin maintenance. How this …

A pervasive view is that undifferentiated stem cells are alone responsible for generating all
other cells and are the origins of cancer. However, emerging evidence demonstrates fully …