Abstract Purpose of Review Juvenile-onset systemic lupus erythematosus ((j) SLE) is an
autoimmune/inflammatory disease that results in significant damage and disability. When …

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease affecting multiple
organs. A complex interaction of genetics, environment, and hormones leads to immune …

Systemic lupus erythematosus is an autoimmune disease characterized by multi-system
involvement and autoantibody production. Abnormal T cell DNA methylation and type-I …

One of the major disappointments in human autoimmunity has been the relative failure on
genome-wide association studies to provide “smoking genetic guns” that would explain the …

Aicardi–Goutières syndrome (AGS) is a severe childhood inflammatory disorder that shows
clinical and genetic overlap with systemic lupus erythematosus (SLE). AGS is thought to …

The immune-regulatory cytokine IL-10 plays a central role during innate and adaptive
immune responses. IL-10 is elevated in the serum and tissues of patients with systemic …

Psoriasis is a symmetric autoimmune/inflammatory disease that primarily affects the skin. In
a significant proportion of cases, it is accompanied by arthritis that can affect any joint, the …

Type I interferons (IFNs), mostly IFNα and IFNβ, and the type I IFN Signature are important in
the pathogenesis of Systemic Lupus Erythematosus (SLE), an autoimmune chronic …

Introduction DNA methylation is an epigenetic mechanism regulating gene expression that
has been insufficiently studied in the blood of rheumatoid arthritis (RA) patients, as only T …

Systemic lupus erythematosus (SLE) is an autoimmune disease well known for its clinical
heterogeneity, and its etiology secondary to a cross-talk involving genetic predisposition and …