Coronaviruses are animal and human pathogens that can cause lethal zoonotic infections
like SARS and MERS. They have polycistronic plus-stranded RNA genomes and belong to …

The 5′ m7G cap is an evolutionarily conserved modification of eukaryotic mRNA. Decades
of research have established that the m7G cap serves as a unique molecular module that …

Genetic robustness, or the ability of an organism to maintain fitness in the presence of
harmful mutations, can be achieved via protein feedback loops. Previous work has …

Regulation of mRNA translation, the process by which ribosomes decode mRNAs into
polypeptides, is used to tune cellular protein levels. Currently, methods for observing the …

Soil microorganisms are central to the provision of food, feed, fiber, and medicine.
Engineering of soil microbiomes may promote plant growth and plant health, thus …

ABSTRACT A major component of the protective antiviral host defense is contributed by the
intracellular actions of the proteins encoded by interferon-stimulated genes (ISGs); among …

African swine fever virus (ASFV) causes hemorrhagic fever in domestic pigs, presenting the
biggest global threat to animal farming in recorded history. Despite the importance of ASFV …

RNA function relies heavily on posttranscriptional modifications. Recently, it was shown that
certain PARPs and TRPT1 can ADP-ribosylate RNA in vitro. Traditionally, intracellular ADP …

In platelets, splicing and translation occur in the absence of a nucleus. However, the integrity
and stability of mRNAs derived from megakaryocyte progenitor cells remain poorly …

Ribosomal recruitment of cellular mRNAs depends on binding of eIF4F to the mRNA's 5′-
terminal 'cap'. The minimal 'cap0'consists of N7-methylguanosine linked to the first …