The topoisomerase enzymes play an important role in DNA metabolism, and searching for
enzyme inhibitors is an important target in the search for new anticancer drugs. Discovery of …

Chemical compounds derived from plants have been used since the origin of human beings
to counteract a number of diseases. Among them, the natural isoquinoline alkaloid …

Alkaloids are used in traditional medicine for the treatment of many diseases. These
compounds are synthesized in plants as secondary metabolites and have multiple effects on …

This contribution reviews some general aspects of the quaternary iminium protoberberine
alkaloids. The alkaloids represent a very extensive group of secondary metabolites with …

Isoquinoline alkaloids-enriched herbal plants have been used as traditional folk medicine
for their anti-inflammatory, antimicrobial, and analgesic effects. They induce cell cycle arrest …

Berberine, an isoquinoline alkaloid derived from a plant used traditionally in Chinese and
Ayurvedic medicine, has been reported to exhibit chemopreventive and anti-inflammatory …

Background: Berberine, a well-known component of the Chinese herbal medicine
Huanglian, has wide range of biochemical and pharmacological effects, including …

Alkaloids occupy an important position in chemistry and pharmacology. Among the various
alkaloids, berberine and coralyne of the protoberberine group, sanguinarine of the …

The interaction of berberine and its 9-substituted derivatives with human telomeric DNA d
[G3 (T2AG3) 3](telo21) has been investigated via CD spectroscopy, fluorescence …

Alkaloid berberine is widely used for the treatment of diarrhea and other diseases. Many
laboratory studies showed that it exhibits anti-proliferative activity against a wide spectrum of …