Adenovirus infections in immunocompetent and immunocompromised patients

T Lion - Clinical microbiology reviews, 2014 - Am Soc Microbiol
Human adenoviruses (HAdVs) are an important cause of infections in both
immunocompetent and immunocompromised individuals, and they continue to provide …

Molecular mechanisms of Dicer: endonuclease and enzymatic activity

MS Song, JJ Rossi - Biochemical journal, 2017 - portlandpress.com
The enzyme Dicer is best known for its role as a riboendonuclease in the small RNA
pathway. In this canonical role, Dicer is a critical regulator of the biogenesis of microRNA …

The interplay between viral-derived miRNAs and host immunity during infection

R Mishra, A Kumar, H Ingle, H Kumar - Frontiers in immunology, 2020 - frontiersin.org
MicroRNAs are short non-coding RNAs that play a crucial role in the regulation of gene
expression during cellular processes. The host-encoded miRNAs are known to modulate the …

LncRNA, miRNA and lncRNA-miRNA interaction in viral infection

L Chen, Y Zhou, H Li - Virus research, 2018 - Elsevier
Noncoding RNAs (ncRNAs) are key components of the transcriptome and play an important
role in both normal biological activity and pathological processes such as viral infection and …

Perspective on adenoviruses: epidemiology, pathogenicity, and gene therapy

BJ Crenshaw, LB Jones, CR Bell, S Kumar… - Biomedicines, 2019 - mdpi.com
Human adenoviruses are large (150 MDa) doubled-stranded DNA viruses that cause
respiratory infections. These viruses are particularly pathogenic in healthy and immune …

Viral noncoding RNAs: more surprises

KT Tycowski, YE Guo, N Lee, WN Moss… - Genes & …, 2015 - genesdev.cshlp.org
Eukaryotic cells produce several classes of long and small noncoding RNA (ncRNA). Many
DNA and RNA viruses synthesize their own ncRNAs. Like their host counterparts, viral …

Long noncoding RNAs in viral infections

P Fortes, KV Morris - Virus research, 2016 - Elsevier
Viral infections induce strong modifications in the cell transcriptome. Among the RNAs
whose expression is altered by infection are long noncoding RNAs (lncRNAs). LncRNAs are …

Pediatric adenovirus pneumonia: clinical practice and current treatment

J Zhang, Y Zhu, Y Zhou, F Gao, X Qiu, J Li… - Frontiers in …, 2023 - frontiersin.org
Adenovirus pneumonia is common in pediatric upper respiratory tract infection, which is
comparatively easy to develop into severe cases and has a high mortality rate with many …

Viral miRNA regulation of host gene expression

NL Diggins, MH Hancock - Seminars in Cell & Developmental Biology, 2023 - Elsevier
Viruses have evolved a multitude of mechanisms to combat barriers to productive infection
in the host cell. Virally-encoded miRNAs are one such means to regulate host gene …

Adenovirus VA RNA: an essential pro-viral non-coding RNA

VK Vachon, GL Conn - Virus research, 2016 - Elsevier
Abstract Adenovirus (AdV)'virus-associated'RNAs (VA RNAs) are exceptionally abundant
(up to 10 8 copies/cell), heterogeneous, non-coding RNA transcripts (∼ 150–200 …