Therapeutic study of cinnamic acid derivative for oxidative stress ablation: The computational and experimental answers

OA Ojo, AD Ogunlakin, RF Maimako, GA Gyebi… - Molecules, 2023 - mdpi.com
This study aimed to examine the therapeutic activity of the cinnamic acid derivative KAD-7
(N′-(2, 4-dichlorobenzylidene)-3-(4-methoxyphenyl) acrylohydrazide) on Fe2+-induced …

Profiling the antidiabetic potential of GC–MS compounds identified from the methanolic extract of Spilanthes filicaulis: experimental and computational insight

OA Ojo, AD Ogunlakin, GA Gyebi… - Journal of …, 2023 - Taylor & Francis
This study examines the nutritional composition, phytochemical profiling, and antioxidant,
antidiabetic, and anti-inflammatory potential of a methanolic extract of Spilanthes filicaulis …

Effect of Triclisia subcordata Oliv.(Menispermaceae) leaves on hormonal imbalance and genes expression in the ovaries of letrozole-induced polycystic rats via in vivo …

AD Ogunlakin, OA Ojo, GA Gyebi, GO Adebodun… - Journal of Molecular …, 2024 - Elsevier
The hormonal imbalance, insulin sensitivity, and ovarian function are among the biological
processes linked to polycystic ovarian syndrome (PCOS). Hence, in PCOS ovaries, the …

Multi-regulator of EZH2-PPARs therapeutic targets: a hallmark for prospective restoration of pancreatic insulin production and cancer dysregulation

CB Olowosoke, O Gbemisola, AA Alaba… - Applied Biochemistry …, 2023 - Springer
The unexpected rise in cancer and diabetes statistics has been a significant global threat,
inciting ongoing research into various biomarkers that can act as innovative therapeutic …

[HTML][HTML] Nutritional, phytochemistry, antioxidant, and antidiabetic potentials of Hippocratea velutina (Afzel.) leaves: in vitro, ex vivo and in silico studies

AA Olanrewaju, AD Ogunlakin, U Obike, GA Gyebi… - Phytomedicine Plus, 2024 - Elsevier
Background Hippocratea velutina is a novel folk plant that is used for lowering blood
glucose and is hence a potential source of new antidiabetic medication. Therefore, this study …

Exploring beetroot (Beta vulgaris L.) for diabetes mellitus and Alzheimer's disease dual therapy: in vitro and computational studies

OA Ojo, GA Gyebi, EH Ezenabor, M Iyobhebhe… - RSC …, 2024 - pubs.rsc.org
This study explored the flavonoid-rich extract of beetroot (Beta vulgaris L.) for type 2
diabetes mellitus (T2D) and Alzheimer's disease (AD) dual therapy by using in vitro and …

Effect of Pentaclethra macrophyla Benth. Leaf on expression of P53, IRS, HsD17β2, FTO, and CYP11a genes in letrozole-induced polycystic ovarian syndrome rats

AD Ogunlakin, OA Ojo, PO Osagie, O Ubogu… - Comparative Clinical …, 2024 - Springer
Hyperandrogenism and menstruation difficulties are the hallmarks of polycystic ovarian
syndrome (PCOS), a disorder affecting women in their reproductive years. The purpose of …

Apoptotic Potential of Iloneoside from Gongronema latifolium Benth against Prostate Cancer Cells Using In Vitro and In Silico Approach

GA Gyebi, SO Afolabi, OM Ogunyemi… - Cell Biochemistry and …, 2024 - Springer
Prostate cancer is a major cause of cancer-related mortality in men worldwide. The anti-
proliferative activity of Gongronema latifolium leaf extracts on some cancer cells has been …

Cholinergic Inhibition and Antioxidant Potential of Gongronema latifolium Benth Leaf in Neurodegeneration: Experimental and In Silico Study

GA Gyebi, JC Ejoh, OM Ogunyemi, SO Afolabi… - Cell Biochemistry and …, 2024 - Springer
The use of Gongronema latifolium for the management of various forms of neurological
disorders has generated a lot of interest in the need to further investigate its …

Antioxidant and anti-arthritic activity of Bombax buonopozense P. Beauv. leaves

OA Fadogba, AD Ogunlakin, AM Ajayi… - Annales …, 2024 - Elsevier
Background and aim Bombax buonopozense (Bombacaceae) leaves have been used
traditionally for arthritis in south-western Nigeria. Therefore, the aim of the study was to …