Despite undeniable advances in modern medicine, lung cancer still has high morbidity and
mortality rates. Lung cancer is preventable and treatable, and it is important to identify new …

Background OSA has been associated with increased incidence and aggressiveness of
melanoma. However, the long-term impact of OSA and CPAP treatment on the prognosis of …

IFN-γ is a pleiotropic cytokine with immunomodulatory and tumoricidal functions. It has been
used as an anti-tumor agent in adjuvant therapies for various cancers. Paradoxically, recent …

Background Intermittent hypoxaemia and obstructive sleep apnoea (OSA) have been linked
to lung cancer through as yet unidentified pathophysiological mechanisms. This study …

Background Mechanical stretch of cancer cells can alter their invasiveness. During
mechanical ventilation, lungs may be exposed to an increased amount of stretch, but the …

Simple Summary Patients with obstructive sleep apnea (OSA) exhibit an intermittent hypoxia-
dependent paraspeckle protein-1 (PSPC1) increase, which is eventually delivered to the …

Midkine (MDK), a secreted growth factor, regulates signal transduction and cancer
progression by interacting with receptors, and it can be internalized into the cytoplasm by …

Extract Although the relationship between obstructive sleep apnoea (OSA) and its main
pathophysiological consequence, intermittent hypoxaemia (IH), with cardiovascular …

Chronotype is the attitude of subjects to carry out their daily activities mainly in the morning
(“lark”) or in the evening (“owl”). The intermediate chronotype is located between these two …

Justificativa/Problema: O conhecimento dos estudos existentes até o momento que
relacionam HI e malignização é necessário para melhorar a prevenção eo tratamento da …