MicroRNA as an important target for anticancer drug development

Z Fu, L Wang, S Li, F Chen, KKW Au-Yeung… - Frontiers in …, 2021 - frontiersin.org
Cancer has become the second greatest cause of death worldwide. Although there are
several different classes of anticancer drugs that are available in clinic, some tough issues …

The function of the HGF/c-Met axis in hepatocellular carcinoma

H Wang, B Rao, J Lou, J Li, Z Liu, A Li, G Cui… - Frontiers in cell and …, 2020 - frontiersin.org
Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide,
leading to a large global cancer burden. Hepatocyte growth factor (HGF) and its high-affinity …

Circular RNA LPAR3 sponges microRNA‐198 to facilitate esophageal cancer migration, invasion, and metastasis

Y Shi, N Fang, Y Li, Z Guo, W Jiang, Y He, Z Ma… - Cancer …, 2020 - Wiley Online Library
In this study, we explored expression and functions of circular RNA LPAR3 (circLPAR3) in
esophageal squamous cell carcinoma (ESCC). The differential expression of circular RNAs …

[HTML][HTML] Targeting oncomiRNAs and mimicking tumor suppressor miRNAs: Νew trends in the development of miRNA therapeutic strategies in oncology

R Gambari, E Brognara… - … journal of oncology, 2016 - spandidos-publications.com
MicroRNA (miRNA or miR) therapeutics in cancer are based on targeting or mimicking
miRNAs involved in cancer onset, progression, angiogenesis, epithelial-mesenchymal …

'See-saw'expression of microRNA-198 and FSTL1 from a single transcript in wound healing

GM Sundaram, JEA Common, FE Gopal, S Srikanta… - Nature, 2013 - nature.com
Post-transcriptional switches are flexible effectors of dynamic changes in gene expression.
Here we report a new post-transcriptional switch that dictates the spatiotemporal and …

Mechanistic actions of microRNAs in diabetic wound healing

M Petkovic, AE Sørensen, EC Leal, E Carvalho… - Cells, 2020 - mdpi.com
Wound healing is a complex biological process that is impaired under diabetes conditions.
Chronic non-healing wounds in diabetes are some of the most expensive healthcare …

Post-transcriptional regulatory network of epithelial-to-mesenchymal and mesenchymal-to-epithelial transitions

F Guo, BC Parker Kerrigan, D Yang, L Hu… - Journal of hematology & …, 2014 - Springer
Epithelial-to-mesenchymal transition (EMT) and its reverse process, mesenchymal-to-
epithelial transition (MET), play important roles in embryogenesis, stem cell biology, and …

Dysregulated miRNA in progression of hepatocellular carcinoma: A systematic review

Y Mizuguchi, T Takizawa, H Yoshida… - Hepatology …, 2016 - Wiley Online Library
Hepatocellular carcinoma (HCC) is the fifth most frequent cancer and the third cause of
cancer‐related mortality worldwide. The primary risk factor for HCC is liver cirrhosis …

Tumor microenviroment and hepatocellular carcinoma metastasis

H Wang, L Chen - Journal of gastroenterology and hepatology, 2013 - Wiley Online Library
The cross talk between tumor cells and the surrounding peritumoral stroma has been
extensively studied as a dynamic system involving the processes of hepatocarcinogenesis …

MicroRNAs in hepatocellular carcinoma: regulation, function, and clinical implications

J Sun, H Lu, X Wang, H Jin - The Scientific World Journal, 2013 - Wiley Online Library
Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide and the
third cause of cancer‐related death. Poor understanding of the mechanisms underlying the …