Autophagy and Alzheimer's disease: from molecular mechanisms to therapeutic implications

MS Uddin, A Stachowiak, AA Mamun… - Frontiers in aging …, 2018 - frontiersin.org
Alzheimer's disease (AD) is the most common cause of progressive dementia in the elderly.
It is characterized by a progressive and irreversible loss of cognitive abilities and formation …

Research progress of polycyclic polyprenylated acylphloroglucinols

XW Yang, RB Grossman, G Xu - Chemical reviews, 2018 - ACS Publications
Polycyclic polyprenylated acylphloroglucinols (PPAPs) are a class of hybrid natural products
sharing the mevalonate/methylerythritol phosphate and polyketide biosynthetic pathways …

[HTML][HTML] Calcium signaling in Alzheimer's disease & therapies

BCK Tong, AJ Wu, M Li, KH Cheung - Biochimica et Biophysica Acta (BBA) …, 2018 - Elsevier
Alzheimer's disease (AD) is the most common type of dementia and is characterized by the
accumulation of amyloid (Aβ) plaques and neurofibrillary tangles in the brain. Much attention …

Astrocytes as a therapeutic target in alzheimer's disease–comprehensive review and recent developments

M Rodríguez-Giraldo, RE González-Reyes… - International Journal of …, 2022 - mdpi.com
Alzheimer's disease (AD) is a frequent and disabling neurodegenerative disorder, in which
astrocytes participate in several pathophysiological processes including neuroinflammation …

Dysregulation of neuronal calcium homeostasis in Alzheimer's disease–A therapeutic opportunity?

E Popugaeva, E Pchitskaya, I Bezprozvanny - Biochemical and biophysical …, 2017 - Elsevier
Alzheimer's disease (AD) is the disease of lost memories. Synaptic loss is a major reason for
memory defects in AD. Signaling pathways involved in memory loss in AD are under intense …

Role of calcium modulation in the pathophysiology and treatment of Alzheimer's disease

D Baracaldo-Santamaría, SS Avendaño-Lopez… - International journal of …, 2023 - mdpi.com
Alzheimer's disease (AD) is a chronic neurodegenerative disease and the most frequent
cause of progressive dementia in senior adults. It is characterized by memory loss and …

miR-135a-5p mediates memory and synaptic impairments via the Rock2/Adducin1 signaling pathway in a mouse model of Alzheimer's disease

K Zheng, F Hu, Y Zhou, J Zhang, J Zheng, C Lai… - Nature …, 2021 - nature.com
Aberrant regulation of microRNAs (miRNAs) has been implicated in the pathogenesis of
Alzheimer's disease (AD), but most abnormally expressed miRNAs found in AD are not …

Neuroprotective Activity of Hypericum perforatum and Its Major Components

AI Oliveira, C Pinho, B Sarmento… - Frontiers in plant …, 2016 - frontiersin.org
Hypericum perforatum is a perennial plant, with worldwide distribution, commonly known as
St. John's wort. It has been used for centuries in traditional medicine for the treatment of …

Voluntary Running Attenuates Memory Loss, Decreases Neuropathological Changes and Induces Neurogenesis in a Mouse Model of A lzheimer's Disease

C Tapia‐Rojas, F Aranguiz, L Varela‐Nallar… - Brain …, 2016 - Wiley Online Library
A lzheimer's disease (AD) is a neurodegenerative disorder characterized by loss of memory
and cognitive abilities, and the appearance of amyloid plaques composed of the amyloid‐β …

[HTML][HTML] Neuroprotective effects of CD4+ CD25+ Foxp3+ regulatory T cells in a 3xTg-AD Alzheimer's disease model

H Baek, M Ye, GH Kang, C Lee, G Lee, DB Choi… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Alzheimer's disease patients display neuropathological lesions, including the accumulation
of amyloid-beta (Aβ) peptide and neurofibrillary tangles. Although the mechanisms causing …