Propolis is a natural product resulting from the mixing of bee secretions with botanical
exudates. Since propolis is rich in flavonoids and cinnamic acid derivatives, the application …

The family of nuclear peroxisome proliferator-activated receptors (PPARα, PPARβ/δ, and
PPARγ) is a set of ligand-activated transcription factors that regulate different functions in the …

Adiponectin-synthesis-promoting compounds possess therapeutic potential to treat diverse
metabolic diseases, including obesity and diabetes. Phenotypic screening to find …

Adiponectin and leptin are major adipocytokines that control crosstalk between adipose
tissue and other organ systems. Hypoadiponectinemia and hypoleptinemia are associated …

Recent studies have identified selective peroxisome proliferator-activated receptor γ
(PPARγ) modulators, which synergistically engage in the inhibition mechanism of PPARγ …

Fractionation of a methanol extract of Orixa japonica leaves led to the identification of five
new quinoline alkaloids (1, 2, 4, 8, and 9), three new coumarins (15, 17, and 19), and 20 …

Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors, and their
activation has been proven to treat mild liver fibrosis, reduce steatosis, inflammation, and the …

Adiponectin is an adipocyte-derived cytokine having an insulin-sensitizing activity. During
the phenotypic screening of secondary metabolites derived from the marine fungus …

The upregulation of adiponectin production has been suggested as a novel strategy for the
treatment of metabolic diseases. Galangin, a natural flavonoid, exhibited adiponectin …

Compounds inducing adiponectin production have therapeutic potential for metabolic
diseases. During screening, heme oxygenase-1-inducing marliolide derivatives were …