DR Dempsey, T Viennet, R Iwase, E Park… - Nature structural & …, 2021 - nature.com
Phosphatase and tensin homolog (PTEN) is a phosphatidylinositol-3, 4, 5-triphosphate (PIP3) phospholipid phosphatase that is commonly mutated or silenced in cancer. PTEN's …
Y Yu, L Zhang, B Li, Z Fu, SG Brohawn… - Nature …, 2024 - nature.com
Voltage-sensing phosphatases (VSPs) dephosphorylate phosphoinositide (PIP) signaling lipids in response to membrane depolarization. VSPs possess an S4-containing voltage …
Y Okamura, Y Okochi - Proceedings of the Japan Academy, Series B, 2019 - jstage.jst.go.jp
The voltage sensor domain (VSD) has long been studied as a unique domain intrinsic to voltage-gated ion channels (VGICs). Within VGICs, the VSD is tightly coupled to the pore …
IC Paixao, N Mizutani, M Matsuda, RT Andriani… - Biophysical …, 2023 - cell.com
Voltage-sensing phosphatase (VSP) consists of the voltage sensor domain (VSD) similar to that of voltage-gated ion channels and the cytoplasmic phosphatase region with remarkable …
JP Giblin, I Etayo, A Castellanos, A Andres-Bilbe… - Molecular …, 2019 - Springer
The background K+ channel TRESK regulates sensory neuron excitability, and changes in its function/expression contribute to neuronal hyperexcitability after injury/inflammation …
The voltage-sensing domain (VSD) is a four-helix modular protein domain that converts electrical signals into conformational changes, leading to open pores and active enzymes. In …
To identify potential regions of the voltage-sensing domain that could shift the voltage sensitivity of Ciona intestinalis based Genetically Encoded Voltage Indicators (GEVIs), we …
A Kawanabe, N Mizutani, OK Polat… - Journal of General …, 2020 - rupress.org
Voltage-sensing phosphatases (VSP) consist of a membrane-spanning voltage sensor domain and a cytoplasmic region that has enzymatic activity toward phosphoinositides (PIs) …
A Kawanabe, M Hashimoto, M Nishizawa, K Nishizawa… - Elife, 2018 - elifesciences.org
Voltage-sensing phosphatases (VSP) contain a voltage sensor domain (VSD) similar to that of voltage-gated ion channels but lack a pore-gate domain. A VSD in a VSP regulates the …