From ancient herb to modern drug: Artemisia annua and artemisinin for cancer therapy

T Efferth - Seminars in cancer biology, 2017 - Elsevier
Artemisia annua L. is used throughout Asia and Africa as tea and press juice to treat malaria
and related symptomes (fever, chills). Its active ingredient, artemisinin (ARS), has been …

Anti-malarial drug, artemisinin and its derivatives for the treatment of respiratory diseases

DHJ Cheong, DWS Tan, FWS Wong, T Tran - Pharmacological research, 2020 - Elsevier
Artemisinins are sesquiterpene lactones with a peroxide moiety that are isolated from the
herb Artemisia annua. It has been used for centuries for the treatment of fever and chills, and …

Artemisinins: pharmacological actions beyond anti-malarial

WE Ho, HY Peh, TK Chan, WSF Wong - Pharmacology & therapeutics, 2014 - Elsevier
Artemisinins are a family of sesquiterpene trioxane lactone anti-malarial agents originally
derived from Artemisia annua L. The anti-malarial action of artemisinins involves the …

Antitumor activity of artemisinin and its derivatives: from a well‐known antimalarial agent to a potential anticancer drug

MP Crespo-Ortiz, MQ Wei - BioMed Research International, 2012 - Wiley Online Library
Improvement of quality of life and survival of cancer patients will be greatly enhanced by the
development of highly effective drugs to selectively kill malignant cells. Artemisinin and its …

The role of traditional Chinese herbal medicines in cancer therapy–from TCM theory to mechanistic insights

WLW Hsiao, L Liu - Planta medica, 2010 - thieme-connect.com
Traditional Chinese medicine-based herbal medicines have gained increasing acceptance
worldwide in recent years and are being pursued by pharmaceutical companies as rich …

Development of artemisinin compounds for cancer treatment

HC Lai, NP Singh, T Sasaki - Investigational new drugs, 2013 - Springer
Artemisinin contains an endoperoxide moiety that can react with iron to form cytotoxic free
radicals. Cancer cells contain significantly more intracellular free iron than normal cells and …

Artemisinins as a novel anti-cancer therapy: targeting a global cancer pandemic through drug repurposing

Y Augustin, HM Staines, S Krishna - Pharmacology & Therapeutics, 2020 - Elsevier
Artemisinins are a unique class of antimalarial drugs with significant potential for drug
repurposing for a wide range of diseases including cancer. Cancer is a leading cause of …

Artemisinin and its derivatives: A promising cancer therapy

BH Kiani, WK Kayani, AU Khayam, E Dilshad… - Molecular Biology …, 2020 - Springer
The world is experiencing a cancer epidemic and an increase in the prevalence of the
disease. Cancer remains a major killer, accounting for more than half a million deaths …

Artemisia: a promising plant for the treatment of cancer

A Taleghani, SA Emami, Z Tayarani-Najaran - Bioorganic & Medicinal …, 2020 - Elsevier
Due to the promising features of the ancient herbal plant Artemisia, its biologic activity has
been investigated for use in modern medicine. In this regard, Artemisia and its active …

Ferroptosis: a novel mechanism of artemisinin and its derivatives in cancer therapy

S Zhu, Q Yu, C Huo, Y Li, L He, B Ran… - Current medicinal …, 2021 - ingentaconnect.com
Background: Artemisinin is a sesquiterpene lactone compound with a special peroxide
bridge that is tightly linked to the cytotoxicity involved in fighting malaria and cancer …