High-resolution structure and strain comparison of infectious mammalian prions
Within the extensive range of self-propagating pathologic protein aggregates of mammals,
prions are the most clearly infectious (eg,∼ 10 9 lethal doses per milligram). The structures …
prions are the most clearly infectious (eg,∼ 10 9 lethal doses per milligram). The structures …
Structural biology of ex vivo mammalian prions
The structures of prion protein (PrP)–based mammalian prions have long been elusive.
However, cryo-EM has begun to reveal the near-atomic resolution structures of fully …
However, cryo-EM has begun to reveal the near-atomic resolution structures of fully …
Pathogenic prion structures at high resolution
Numerous proteins are known to form ordered, self-propagating aggregates as underlying
causes of neurodegeneration in proteinopathies such as Alzheimer's, Parkinson's, and prion …
causes of neurodegeneration in proteinopathies such as Alzheimer's, Parkinson's, and prion …
Parallel in-register intermolecular β-sheet architectures for prion-seeded prion protein (PrP) amyloids
BR Groveman, MA Dolan, LM Taubner, A Kraus… - Journal of Biological …, 2014 - ASBMB
Structures of the infectious form of prion protein (eg PrP Sc or PrP-Scrapie) remain poorly
defined. The prevalent structural models of PrP Sc retain most of the native α-helices of the …
defined. The prevalent structural models of PrP Sc retain most of the native α-helices of the …
The structure of the infectious prion protein: experimental data and molecular models
JR Requena, H Wille - Prion, 2014 - Taylor & Francis
The structures of the infectious prion protein, PrPSc, and that of its proteolytically truncated
variant, PrP 27–30, have evaded experimental determination due to their insolubility and …
variant, PrP 27–30, have evaded experimental determination due to their insolubility and …
Structure of an infectious mammalian prion
A Kraus, F Hoyt, CL Schwartz, B Hansen, AG Hughson… - BioRxiv, 2021 - biorxiv.org
Classical mammalian prions are assemblies of prion protein molecules that are
extraordinarily transmissible, with a microgram of protein containing up to 108 lethal doses …
extraordinarily transmissible, with a microgram of protein containing up to 108 lethal doses …
Prions and the potential transmissibility of protein misfolding diseases
A Kraus, BR Groveman… - Annual review of …, 2013 - annualreviews.org
Prions, or infectious proteins, represent a major frontier in the study of infectious agents. The
prions responsible for mammalian transmissible spongiform encephalopathies (TSEs) are …
prions responsible for mammalian transmissible spongiform encephalopathies (TSEs) are …
Toward the molecular basis of inherited prion diseases: NMR structure of the human prion protein with V210I mutation
The development of transmissible spongiform encephalopathies (TSEs) is associated with
the conversion of the cellular prion protein (PrPC) into a misfolded, pathogenic isoform …
the conversion of the cellular prion protein (PrPC) into a misfolded, pathogenic isoform …
[HTML][HTML] Heparin binding confers prion stability and impairs its aggregation
The conversion of the prion protein (PrP) into scrapie PrP (PrP Sc) is a central event in prion
diseases. Several molecules work as cofactors in the conversion process, including …
diseases. Several molecules work as cofactors in the conversion process, including …
Common structural traits across pathogenic mutants of the human prion protein and their implications for familial prion diseases
Human (Hu) familial prion diseases are associated with about 40 point mutations of the
gene coding for the prion protein (PrP). Most of the variants associated with these mutations …
gene coding for the prion protein (PrP). Most of the variants associated with these mutations …