The discovery of the genetic code and tRNAs as decoders of the code transformed life
science. However, after establishing the role of tRNAs in protein synthesis, the field moved …

Codon usage bias, the preference for certain synonymous codons, is found in all genomes.
Although synonymous mutations were previously thought to be silent, a large body of …

Decoding the information in mRNA during protein synthesis relies on tRNA adaptors, the
abundance of which can affect the decoding rate and translation efficiency. To determine …

mRNA translation and decay appear often intimately linked although the rules of this
interplay are poorly understood. In this study, we combined our recent P-body transcriptome …

Although protein synthesis dynamics has been studied both with theoretical models and by
profiling ribosome footprints, the determinants of ribosome flux along open reading frames …

Dynamic regulation of mRNA translation initiation and elongation is essential for the survival
and function of neural cells. Global reductions in translation initiation resulting from …

Transfer RNAs are essential for translating genetic information into proteins. The human
genome contains hundreds of predicted tRNA genes, many in multiple copies. How their …

Selection on codon usage bias is well documented in a number of microorganisms. Whether
codon usage is also generally shaped by natural selection in large organisms, despite their …

In the human genome, most genes undergo splicing, and patterns of codon usage are
splicing dependent: guanine and cytosine (GC) content is the highest within single-exon …

Objective To better comprehend transcriptional phenotypes of cancer cells, we globally
characterised RNA-binding proteins (RBPs) to identify altered RNAs, including long non …