Driver mutations in oncogenic pathways, rewiring of cellular metabolism and altered ROS
homoeostasis are intimately connected hallmarks of cancer. Electrons derived from different …

Reducing infarct size during a cardiac ischaemic‐reperfusion episode is still of paramount
importance, because the extension of myocardial necrosis is an important risk factor for …

Abstract ATPase Inhibitory Factor 1 (IF1) regulates the activity of mitochondrial ATP
synthase. The expression of IF1 in differentiated human and mouse cells is highly variable …

Mitochondrial metabolism has emerged as a promising target against the mechanisms of
tumor growth. Herein, we have screened an FDA-approved library to identify drugs that …

The coexistence of two pools of ATP synthase in mitochondria has been largely neglected
despite in vitro indications for the existence of reversible active/inactive state transitions in …

The pentatricopeptide repeat (PPR) family plays a major role in RNA stability, regulation,
processing, splicing, translation, and editing. Leucine-rich PPR-motif-containing protein …

Significance: The mitochondrial oxidative phosphorylation (OXPHOS) system, comprising
the electron transport chain and ATP synthase, generates membrane potential, drives ATP …

The hydrolytic activity of the ATP synthase in bovine mitochondria is inhibited by a protein
called IF 1, but bovine IF 1 has no effect on the synthetic activity of the bovine enzyme in …

The mitochondrial ATP synthase emerges as key hub of cellular functions controlling the
production of ATP, cellular signaling, and fate. It is regulated by the ATPase inhibitory factor …

Simple Summary Cancer is a global health problem with high personal and economic
burden worldwide. The reprogramming of metabolism experienced by carcinomas offers a …