Cerebral plasticity: Windows of opportunity in the developing brain
Background Neuroplasticity refers to the inherently dynamic biological capacity of the central
nervous system (CNS) to undergo maturation, change structurally and functionally in …
nervous system (CNS) to undergo maturation, change structurally and functionally in …
Dystonia
Dystonia is a neurological condition characterized by abnormal involuntary movements or
postures owing to sustained or intermittent muscle contractions. Dystonia can be the …
postures owing to sustained or intermittent muscle contractions. Dystonia can be the …
Striatal cholinergic dysfunction as a unifying theme in the pathophysiology of dystonia
KLE Jaunarajs, P Bonsi, MF Chesselet… - Progress in …, 2015 - Elsevier
Dystonia is a movement disorder of both genetic and non-genetic causes, which typically
results in twisted posturing due to abnormal muscle contraction. Evidence from dystonia …
results in twisted posturing due to abnormal muscle contraction. Evidence from dystonia …
Dystonia genes functionally converge in specific neurons and share neurobiology with psychiatric disorders
Dystonia is a neurological disorder characterized by sustained or intermittent muscle
contractions causing abnormal movements and postures, often occurring in absence of any …
contractions causing abnormal movements and postures, often occurring in absence of any …
[HTML][HTML] The integrated stress response in brain diseases: A double-edged sword for proteostasis and synapses
ER Lockshin, N Calakos - Current Opinion in Neurobiology, 2024 - Elsevier
The integrated stress response (ISR) is a highly conserved biochemical pathway that
regulates protein synthesis. The ISR is activated in response to diverse stressors to restore …
regulates protein synthesis. The ISR is activated in response to diverse stressors to restore …
Hyperkinetic disorders and loss of synaptic downscaling
Recent clinical and preclinical studies have shown that hyperkinetic disorders such as
Huntington's disease, dystonia and l-DOPA-induced dyskinesia in Parkinson's disease are …
Huntington's disease, dystonia and l-DOPA-induced dyskinesia in Parkinson's disease are …
Functional genomic analyses of mendelian and sporadic disease identify impaired eIF2α signaling as a generalizable mechanism for dystonia
JE Rittiner, ZF Caffall, R Hernandez-Martinez… - Neuron, 2016 - cell.com
Dystonia is a brain disorder causing involuntary, often painful movements. Apart from a role
for dopamine deficiency in some forms, the cellular mechanisms underlying most dystonias …
for dopamine deficiency in some forms, the cellular mechanisms underlying most dystonias …
Striatal synaptic dysfunction in dystonia and levodopa-induced dyskinesia
M Scarduzio, EJ Hess, DG Standaert… - Neurobiology of …, 2022 - Elsevier
This review provides an overview of the synaptic dysfunctions of neuronal circuits and
underlying neurochemical alterations observed in the hyperkinetic movement disorders …
underlying neurochemical alterations observed in the hyperkinetic movement disorders …
Early structural and functional plasticity alterations in a susceptibility period of DYT1 dystonia mouse striatum
The onset of abnormal movements in DYT1 dystonia is between childhood and
adolescence, although it is unclear why clinical manifestations appear during this …
adolescence, although it is unclear why clinical manifestations appear during this …
Anticholinergic drugs rescue synaptic plasticity in DYT1 dystonia: Role of M1 muscarinic receptors
Broad‐spectrum muscarinic receptor antagonists have represented the first available
treatment for different movement disorders such as dystonia. However, the specificity of …
treatment for different movement disorders such as dystonia. However, the specificity of …