The evolution of ovarian carcinoma subclassification

M Köbel, EY Kang - Cancers, 2022 - mdpi.com
Simple Summary Historically, cancers presenting with their main tumor mass in the ovary
have been classified as ovarian carcinomas (a concise term for epithelial ovarian cancer) …

Low-grade serous ovarian cancer: state of the science

B Slomovitz, C Gourley, MS Carey, A Malpica… - Gynecologic …, 2020 - Elsevier
In January 2019, a group of basic, translational, and clinical investigators and patient
advocates assembled in Miami, Florida, to discuss the current state of the science of low …

Optimized p53 immunohistochemistry is an accurate predictor of TP53 mutation in ovarian carcinoma

M Köbel, AM Piskorz, S Lee, S Lui… - The Journal of …, 2016 - Wiley Online Library
TP53 mutations are ubiquitous in high‐grade serous ovarian carcinomas (HGSOC), and the
presence of TP53 mutation discriminates between high and low‐grade serous carcinomas …

An immunohistochemical algorithm for ovarian carcinoma typing

M Köbel, K Rahimi, PF Rambau… - International Journal …, 2016 - journals.lww.com
There are 5 major histotypes of ovarian carcinomas. Diagnostic typing criteria have evolved
over time, and past cohorts may be misclassified by current standards. Our objective was to …

Type-specific cell line models for type-specific ovarian cancer research

MS Anglesio, KC Wiegand, N Melnyk, C Chow… - PloS one, 2013 - journals.plos.org
Background Ovarian carcinomas consist of at least five distinct diseases: high-grade serous,
low-grade serous, clear cell, endometrioid, and mucinous. Biomarker and molecular …

[HTML][HTML] Molecular profiling of low grade serous ovarian tumours identifies novel candidate driver genes

SM Hunter, MS Anglesio, GL Ryland, R Sharma… - Oncotarget, 2015 - ncbi.nlm.nih.gov
Low grade serous ovarian tumours are a rare and under-characterised histological subtype
of epithelial ovarian tumours, with little known of the molecular drivers and facilitators of …

Low-grade serous carcinoma of the ovary: the current status

A Babaier, H Mal, W Alselwi, P Ghatage - Diagnostics, 2022 - mdpi.com
Low-grade serous carcinoma (LGSC) of the ovary is a rare histological subtype of epithelial
ovarian carcinoma. It has distinct clinical behavior and a specific molecular profile …

Ovarian carcinoma histotype determination is highly reproducible, and is improved through the use of immunohistochemistry

M Köbel, J Bak, BI Bertelsen, O Carpen… - …, 2014 - Wiley Online Library
Aims To assess the variation in ovarian carcinoma type diagnosis among gynaecological
pathologists from Nordic countries, and whether a rationally designed panel of …

KRAS (but not BRAF) mutations in ovarian serous borderline tumour are associated with recurrent low‐grade serous carcinoma

YT Tsang, MT Deavers, CC Sun… - The Journal of …, 2013 - Wiley Online Library
BRAF and KRAS mutations in ovarian serous borderline tumours (OSBTs) and ovarian low‐
grade serous carcinomas (LGSCs) have been previously described. However, whether …

British Gynaecological Cancer Society (BGCS) epithelial ovarian/fallopian tube/primary peritoneal cancer guidelines: recommendations for practice

C Fotopoulou, M Hall, D Cruickshank, H Gabra… - European Journal of …, 2017 - Elsevier
Epithelial ovarian cancer (EOC) is the 6th most common cancer among women in the UK
(2014) and accounts for 4% of all new cases of cancer in females: it has the highest mortality …